摘要
目的基于数据挖掘分析溃疡性结肠炎(ulcerative colitis,UC)的中医用药规律。方法搜集并筛选近十年发表与中医药治疗UC相关的文献,对证型和药物信息进行提取、规范,构建数据库并应用聚类分析、关联规则等方法进行数据挖掘。结果本研究共提取方剂243首,药物188种,高频用药为甘草、白术、黄连、党参、白芍等28种,以补虚药及清热药为主,药性以温、寒、平为先,五味则偏苦、甘味,用药大多归脾胃经。运用Modeler 15.0软件在S≥14%,C≥90%,L≥1.0条件下挖掘出28个药物关联规则,聚类出6个组方并与各证型相对应。结论UC证型分布以大肠湿热证、脾肾阳虚证、肝郁脾虚证、脾虚湿困证、脾气虚证、寒热错杂证为主。核心用药多味苦、甘,入脾胃经,功效上以补虚、清热、理气、收涩、渗湿、温里药为主。组方多为四君子汤、参苓白术散等经典方加减而成,药物配伍上体现了从脾论治的治疗思想,清热除湿、调气理血并重,后期注重补火助阳,多药相合,多法并用以标本兼治。
Objective To analyze the law of traditional Chinese medicine(TCM)for ulcerative colitis(UC)based on data mining technology.Method To collect and screen the literature related to the treatment of UC with TCM published in recent 10 years,and to extract and standardize the syndrome type and drug information form the literature.The database was established by this information,and data mining methods such as clustering analysis and association rules were applied to explore the medication rule of UC.Result This study included 243 prescriptions and 188 kingds of drugs.It was found that high-frequency medications were 28 kingds such as Licorice,Atractylodes macrocephala Koidz,Coptis chinensis,Codonopsis pilosula and Paeonia lactiflora Pall.The most of TCM were tonic medicine and heat-clearing medicine,and most of the medications belonged to the spleen and stomach.The medicinal properties were mainly warm,cold,and flat,while the five flavors were mainly bitter and sweet.Using Modeler 15.0 software,28 drug association rules were excavated under the condition of S≥14%,C≥90%,L≥1.0,and 6 groups were clustered and corresponding to each syndrome type.Conclusion The main clinical syndromes of UC are large intestine dampness syndrome,spleen and kidney yang deficiency syndrome,liver stagnation and spleen deficiency syndrome,spleen deficiency and dampness Stagnation syndrome,Pi-qi deficiency syndrome,intermingled heat and cold syndrome.The core drug is mainly based on drugs such as bitterness and sweetness into the spleen and stomach,most of them are tonic medicine,heat-clearing medicine,Qi-regulation medicine,astringent medicine,diuresis and removing dampness drugs and warming interior drugs.Most of the prescriptions were added and subtracted from classical prescriptions such as Sijunzi Decoction and Shenling Baizhu San.The compatibility of medicines reflects the treatment idea from the spleen.In addition,both clearing heat and removing dampness,regulating qi and regulating blood circulation should be emphasized,and warming kidney and Promoting Yang should be emphasized in the later stage of disease.Multi-drug combination,multi-method treatment to achieve the purpose of treating both manifestation and root cause of disease.
作者
彭卓嵛
陶丽芬
蓝斯莹
蔡林坤
李桂贤
Peng Zhuoyu;Tao Lifen;Lan Siying;Cai Linkun;Li Guixian(The First Affiliated Hospital of Guangxi University of Chinese Medicin,Nanning 530022,China;Guangxi University of Chinese Medicine,Nanning 530001,China)
出处
《世界科学技术-中医药现代化》
CSCD
北大核心
2020年第7期2269-2275,共7页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
国家自然科学基金委员会地区基金项目(81260532):加味柴芍六君颗粒对TRL-NF-ΚB/SOCS串流介导UC免疫失衡的调节效应,负责人:李桂贤
关键词
溃疡性结肠炎
数据挖掘
用药规律
证型分布
Ulcerative colitis
Data mining
Medication rules
Syndrome distribution
