摘要
间充质干细胞源性细胞外囊泡(MSC-EVs)是细胞间信息传递的载体,在生理、病理过程中发挥着重要作用。MSC-EVs、MSC-EVs-microRNA及基因修饰的MSC-EVs参与多种肝脏疾病的发生、发展,发挥减轻肝细胞损伤、促进肝细胞再生、抑制肝纤维化、调节肝脏免疫、减轻肝脏氧化应激、抑制肝癌发生等保护作用,将代替MSCs成为无细胞治疗的研究热点。现就MSC-EVs在肝脏疾病中的研究进展进行综述介绍,为临床肝脏疾病无细胞治疗提供新的依据。
Mesenchymal stem cell-derived extracellular vesicles(MSC-EVs)transport and transmit intercellular information and play an essential role in physiological and pathological processes.MSC-EVs,MSC-EVs-microRNA,and genetically modified MSC-EVs are involved in the onset and progression of different liver diseases and play a role in reducing liver cell damage,promoting liver cell regeneration,inhibiting liver fibrosis,regulating liver immunity,alleviating liver oxidative stress,inhibiting liver cancer occurrence,and others.Hence,it will replace MSCs as a research hotspot for cell-free therapy.This article reviews the research progress of MSC-EVs in liver diseases and provides a new basis for cell-free therapy of clinical liver diseases.
作者
杨柳
冯百岁
Yang Liu;Feng Baisui(Department of Gastroenterology,the Second Affiliated Hospital,Zhengzhou University,Zhengzhou 450000,China)
出处
《中华肝脏病杂志》
CAS
CSCD
北大核心
2023年第5期556-560,共5页
Chinese Journal of Hepatology
关键词
肝疾病
间充质干细胞
外分泌囊泡
微小RNA
Liver disease
Mesenchymal stem cells
Extracellular vesicles
MicroRNA
