摘要
对４６６例ＨＢＶ慢性无症状携带者（ＡＳＣ）进行了为期３年的临床、肝活检及血清标志物的动态观察研究。在此期间，４６６例中有４６例出现临床显性发病，约占样本的１０％，可能与饮酒量过多、乱用药物、精神紧张等因素有关。１４例行第２次肝穿刺，提示：原肝组织正常者几年内相当稳定，病理很少变化，原有病理改变者不易恢复。ＡＳＣＨＢｓＡｇ每年转阴率为１．６３％，抗－ＨＢｓ年转阳率为０．３４％，ＨＢｅＡｇ年转阴率为３．８５％，抗－ＨＢｅ年转阳率为２．７４％，抗－ＨＢｃ无１例阴转。
three-year
follow-up study of the clinic manifestations,liver his-topathology serumHBV markers were made
on 466 asymptomatic HBV carriers(ASC).During this period 46patients(10%)became
symptomatic and this presumably could be attributed to alcoholicindulgence,medicinals abuse
and mental stress.Second liver biopsy was carried out in l4patients and the results revealed
that the conditions of the patients with priorl normal liverbiopsy remained so in the following
years,but the patients with previous abnormal liverbiopsy scarcely recovered.In patients with
ASC,the annual seroconversion rate of HBsAgwas l.63%,that of anti-HBs was 0.34%. The annual
seroconversion rates of HBeAg,anti-HBeand anti-HBc were 3.85%,2.74%,and o,respectively.
出处
《中华消化杂志》
CAS
CSCD
北大核心
1994年第2期80-82,共3页
Chinese Journal of Digestion
关键词
乙型肝炎
表面抗原
携带者
肝活检
Hepatitis B
Asymptonatic carrier
Hepato-histopathology. Serum HBV
markers
Follow-up study.
