摘要
目的探讨血清白细胞介素-10(IL-10)、胰岛素样生长因子-1(IGF-1)水平与食管癌术后复发转移的相关性。方法进行前瞻性研究。抽取2019年6月至2021年6月安阳市肿瘤医院收治的符合选择标准的食管癌患者106例。所有患者术后48 h时均接受血清IL-10、IGF-1检查。术后随访1年,将随访期间食管癌术后复发转移的患者纳入复发转移组,未发生食管癌术后复发转移的患者纳入未复发转移组。同时设计患者基线资料调查表,将可能的因素纳入研究,重点分析血清IL-10、IGF-1与食管癌患者术后复发转移的相关性。结果随访期间,106例行胸腔镜食管癌切除术治疗的患者中术后出现复发转移41例,所占比例为38.68%(41/106)。复发转移组术后48 h血清IL-10、IGF-1水平均高于未复发转移组,差异有统计学意义(P<0.05);复发转移组癌组织浸润程度、TNM分期与未复发转移组比较,差异有统计学意义(P<0.05)。经Logistic回归分析检验结果显示,食管癌患者术后血清高IL-10、IGF-1水平与其术后复发转移有关(P<0.05)。绘制受试者工作特征曲线,结果显示食管癌患者术后血清IL-10、IGF-1单独预测及联合预测其术后复发转移的曲线下面积均>0.7,均具有一定的预测价值,其中联合预测价值高于单一指标预测。结论食管癌患者术后高IL-10、IGF-1水平与其术后复发转移有关,且联合检测二者水平可用于预测食管癌患者术后复发转移风险。
Objective To investigate the correlation of serum interleukin-10(IL-10)and insulin-like growth factor-1(IGF-1)with postoperative recurrence and metastasis in patients with esophageal cancer.Methods The prospective study was conducted.A total of 106 patients with esophageal cancer who met the inclusion criteria treated in Anyang Tumor Hospital from June 2019 to June 2021 were selected for the study.All patients received serum IL-10 and IGF-1 examination at 48 hours after operation.Patients were followed up for 1 year after operation.Patients with postoperative recurrence and metastasis of esophageal cancer during the follow-up period were included in the recurrence and metastasis group,and patients without postoperative recurrence and metastasis of esophageal cancer during the follow-up period were included in the non recurrence and metastasis group.At the same time,the questionnaire of patients’baseline data was designed,and possible factors were enrolled into the study for correlation of serum IL-10 and IGF-1 with postoperative recurrence and metastasis of esophageal cancer patients.Results During the follow-up period,among 106 patients with thoracoscopic esophagectomy,41 cases had postoperative recurrence and metastasis,accounting for 38.68%(41/106).The levels of serum IL-10 and IGF-1 in the recurrence and metastasis group were significantly higher than those in the non recurrence and metastasis group at 48 hours after operation(P<0.05).There was a significant difference in the degree of invasion and TNM stage between the recurrence and metastasis group and the non recurrence and metastasis group(P<0.05).Results of Logistic regression analysis showed that the high levels of serum IL-10 and IGF-1 in patients with esophageal cancer were related to postoperative recurrence and metastasis(P<0.05).Results of the receiver operating characteristic curve showed that the area under the curve of IL-10,IGF-1 and combination of them were all>0.7 in prediction on prognosis and metastasis of esophageal cancer,suggesting a certain predictive value,moreover,predictive value of the combination is higher than that of the two single indexes.Conclusions The high levels of serum IL-10 and IGF-1 in patients with esophageal cancer are related to their postoperative recurrence and metastasis,and the combined detection of the two indexes can be used to predict the risk of recurrence and metastasis in patients with esophageal cancer.
作者
苏文中
Su Wenzhong(Department of Cardiothoracic Surgery,Anyang Tumor Hospital,Anyang 455000,China)
出处
《中国实用医刊》
2022年第20期37-41,共5页
Chinese Journal of Practical Medicine
