摘要
目的探讨维生素D辅助治疗妊娠期糖尿病(GDM)的临床效果。方法抽取2018年8月至2020年7月滨州市中心医院收治的GDM孕妇91例,依据治疗方案将其分为两组。对照组46例行常规胰岛素降糖治疗,观察组45例在对照组基础上辅用维生素D治疗。回顾性对照分析两组孕妇糖代谢指标、脂肪细胞因子及新生儿并发症情况。结果治疗后,观察组孕妇空腹血糖、餐后2 h血糖、糖化血红蛋白、瘦素水平低于对照组(t=6.422、7.139、5.705、8.133,P<0.05),脂联素水平高于对照组(t=13.521,P<0.05)。新生儿并发症中,观察组巨大儿发生率为8.89%(4/45)、黄疸发生率为11.11%(5/45),对照组相应值分别为26.09%(12/46)、28.26%(13/46),两组比较差异有统计学意义(P<0.05)。结论维生素D可辅助改善GDM孕妇糖代谢指标,有效调节脂肪细胞因子,降低新生儿并发症发生率。
Objective To investigate the clinical effect of vitamin D adjuvant therapy on gestational diabetes mellitus(GDM).Methods A total of 91 pregnant women with GDM who were admitted to Binzhou Central Hospital from August 2018 to July 2020 were selected and divided into two groups according to the treatment plan.Forty-six patients in the control group received conventional insulin hypoglycemic treatment,and 45 patients in the observation group received supplemental vitamin D therapy on the basis of the control group.The glucose metabolism indexes,adipocytokines and neonatal complications in the two groups of pregnant women were compared and analyzed retrospectively.Results After treatment,the levels of fasting plasma glucose,postprandial 2-hour plasma glucose,glycosylated hemoglobin and leptin in the observation group were lower than those in the control group(t=6.422,7.139,5.705,8.133,P<0.05),the level of adiponectin in the observation group was higher than that in the control group(t=13.521,P<0.05).Among the neonatal complications,the incidence of macrosomia in the observation group was 8.89%(4/45)and the incidence of jaundice was 11.11%(5/45).The corresponding values in the control group were 26.09%(12/46)and 28.26%(13/46),respectively.The differences were significant between the two groups(P<0.05).Conclusions Vitamin D can help improve the glucose metabolism of pregnant women with GDM,effectively regulate adipocytokines,and reduce the incidence of neonatal complications.
作者
马传燕
张洪星
王桃
张鹏
Ma Chuanyan;Zhang Hongxing;Wang Tao;Zhang Peng(Second Department of Obstetrics,Binzhou Central Hospital,Binzhou 251700,China;First Department of Obstetrics,Binzhou Central Hospital,Binzhou 251700,China)
出处
《中国实用医刊》
2021年第4期104-106,共3页
Chinese Journal of Practical Medicine
关键词
糖尿病
妊娠
维生素D
糖代谢
Diabetes mellitus
Pregnancy
Vitamin D
Glucose metabolism
