摘要
目的探讨妊娠期糖尿病(gestational diabetes mellitus,GDM)发生的影响因素及其对母婴结局的影响。方法选取行常规产检的符合纳入及排除标准的84例GDM孕妇作为研究组,同期行常规产检的正常孕妇120例作为对照组,比较两组一般资料及妊娠、围生儿不良结局,采用多因素Logistic回归分析探讨GDM发生的影响因素。结果两组年龄、孕前体质量指数(BMI)、文化程度、糖尿病家族史、产次、流产次数、孕早期血红蛋白(Hb)及C反应蛋白(CRP)水平比较差异均有统计学意义(P<0.05或P<0.01)。多因素Logistic回归分析结果显示,年龄≥35岁、孕前BMI≥25 kg/m 2、有糖尿病家族史、流产次数≥3次、孕早期Hb≥130 g/L及孕早期CRP≥8 mg/L是GDM发生的危险因素(P<0.05或P<0.01)。妊娠不良结局总发生率研究组为33.33%高于对照组6.67%,围生儿不良结局总发生率研究组为53.57%高于对照组20.00%,差异均有统计学意义(P<0.01)。结论年龄≥35岁、孕前BMI≥25 kg/m 2、有糖尿病家族史、流产次数≥3次、孕早期Hb≥130 g/L及孕早期CRP≥8 mg/L是GDM发生的危险因素,且GDM对母婴结局影响较大。临床应重视存在GDM危险因素孕妇的管理,早期筛查并采取针对性干预措施使孕妇血糖控制在合理范围内,以保证母婴健康。
Objective To explore the influencing factors of gestational diabetes mellitus(GDM)and its effect on the outcome of mother and infant.Methods Eighty-four cases of GDM pregnant women who underwent routine obstetric examination and met the inclusion and exclusion criteria were selected as the research group,and 120 cases of healthy pregnant women who underwent routine obstetric examination were selected as the control group.The general data,adverse pregnancy and adverse perinatal outcomes of the two groups were compared.Multivariate Logistic regression analysis was used for analysis of factors affecting the occurrence of GDM.Results There were significant differences in age,pre-pregnancy body mass index(BMI)before pregnancy,education level,family history of diabetes mellitus(DM),parity,abortion frequency,Hb level in early pregnancy and CRP level in early pregnancy between the two groups(P<0.05 or P<0.01).Multivariate logistic regression analysis showed that age≥35 years,pre-pregnancy BMI≥25 kg/m 2,family history of DM,abortion frequency≥3 times,Hb≥130 g/L and CRP in early pregnancy≥8 mg/L were risk factors for GDM(P<0.05 or P<0.01).The total incidence of adverse pregnancy outcomes was 33.33%in the research group,which was higher than 6.67%in the control group.The total incidence of adverse perinatal outcomes in the research group was 53.57%,which was higher than 20.00%in the control group(P<0.01).Conclusion Age≥35 years,pre-pregnancy BMI≥25 kg/m 2,family history of DM,number of abortion≥3 times,Hb≥130 g/L in early pregnancy and CRP≥8 mg/L in early pregnancy are risk factors for GDM,and GDM has a greater impact on maternal and infant outcomes.Therefore,we should pay attention to the management of pregnant women with risk factors of GDM,early screening and targeted intervention measures to control the blood glucose of pregnant women within a reasonable range,so as to ensure maternal and infant health.
作者
杨帆
马晓娟
YANG Fan;MA Xiao-juan(Department of Obstetrics,People's Hospital of Langfang,Langfang,Hebei 065000,China;Department of Obstetrics,Youai Hospital of Hebei Province,Shijiazhuang 050000,China)
出处
《临床误诊误治》
2020年第11期80-84,共5页
Clinical Misdiagnosis & Mistherapy
基金
河北省医学科学研究重点课题计划项目(20191084)。
