摘要
目的探讨趋化因子受体4(CXCR4)在三阴性乳腺癌中的表达及与复发转移预后的关系。方法收集我院2015年5月~2018年1月的160例三阴性乳腺癌患者的组织,利用免疫组化法对CXCR4的表达进行分析,对其临床病理特征及CXCR4与无疾病进展时间、总生存时间的关系进行分析。结果三阴性乳腺癌患者的年龄、腋窝淋巴结、CXCR4组间无病生存期(DFS)比较,差异有统计学意义(P<0.001)。年龄≤45岁、腋窝淋巴结阳性、CXCR4阳性有较短的DFS。CXCR4阳性较CXCR4阴性有更短的总生存期(OS)。结论CXCR4过表达不仅是肿瘤侵袭性的标志,也可能是三阴性乳腺癌患者预后不良的标志。
Objective To investigate the expression of the chemokine receptor 4(CXCR4)in triple negative breast cancer and its relationship with the prognosis of recurrence and metastasis.Methods A total of 160 cases of triple negative breast cancer from May 2015 to January 2018 in our hospital were collected,immunohistochemistry was used to analyze the expression of CXCR4.The clinicopathological features and the relationship between CXCR4,time of disease progression and total survival were analyzed.Results There were significant differences in the age,axillary lymph nodes and disease-free survival(DFS)of CXCR4 group(P<0.001).There were shorter DFS with age≤45 years old,axillary lymph node positive and CXCR4 positive.The overall survival(OS)of CXCR4 positive patients was shorter than that of CXCR4 negative patients.Conclusion CXCR4 overexpression is not only a marker of tumor invasiveness,but also a marker of poor prognosis in triple negative breast cancer patients.
作者
唐超莉
TANG Chao-li(Department of Oncology,Chongzuo People′s Hospital,Guangxi Zhuang Autonomous Region,Chongzuo532200,China)
出处
《中国当代医药》
2020年第19期118-121,共4页
China Modern Medicine
基金
广西壮族自治区崇左市科技计划项目(崇科攻2018018)。
关键词
三阴性乳腺癌
趋化因子受体4
无疾病进展期
总生存期
Triple negative breast cancer
Chemokine receptor 4
Disease free survival
Overall survival
