摘要
目的研究紧密连接蛋白claudin-1在皮肤基底细胞癌(BCC)组织中的表达,初步探讨claudin-1在BCC发病机制中的作用。方法收集2014年11月—2016年11月苏州市吴江区中医医院38例BCC患者的组织标本,以其对应的癌旁正常皮肤组织作为对照组,采用免疫组化法检测癌旁正常皮肤组织和BCC组织中claudin-1蛋白的表达。结果在癌旁正常皮肤组织中,claudin-1蛋白主要表达于表皮基底层至颗粒层的角质形成细胞膜上,呈强阳性表达,阳性率可高达100%,显著高于BCC的21.05%,两者比较差异有统计学意义(P<0.05)。结论claudin-1蛋白表达下调可能与BCC的发生、发展密切相关。
Objective To research the expression of claudin-1 in basal cell carcinoma and its potential mechanism.Methods 38 cases of basal cell carcinoma specimen from November 2014 to November 2016 at department of pathology in Wujiang Hospital of triditional Chinese Medicine were collected in the study.The expression of claudin-1 in basal cell carcinoma and corresponding normal skin tissues were detected by immunohistochemistry.Results claudin-1 expressed mainly on the cell membrane from epidermal basal layer to granular layer,and its positivity rate was significantly higher in normal tissues than in cancer tissues(100.00%vs 21.05%,P<0.05).Conclusion The down regulation of claudin-1 expression may promote the occurrence and progression of basal cell carcinoma.
作者
黄秋红
潘永年
钱昇
蓝吉
HUANG Qiu-hong;PAN Yong-nian;QIAN Sheng(Department of Dermatology,Wujiang Hospital of Triditional Chinese Medicine,Suzhou 215000,China)
出处
《实用皮肤病学杂志》
2020年第2期95-97,共3页
Journal of Practical Dermatology
基金
苏州市吴江区卫生局2014年度“科技兴卫”卫生科技项目(WWK201427)。
