摘要
目的:探讨上皮性卵巢肿瘤组织中Smac的表达及临床意义。方法:采用免疫组化技术分别检测20例正常卵巢、25例良性上皮性卵巢肿瘤及55例上皮性卵巢癌组织中Smac蛋白表达水平。结果:Smac蛋白在上皮性卵巢癌组织中的阳性表达率为45.45%,明显低于良性卵巢上皮性肿瘤组织76%和正常卵巢组织90%,且上皮性恶性卵巢肿瘤化疗患者组织中的Smac表达高于未化疗患者,经统计学分析差异具有显著性(P<0.05)。结论:Smac在上皮性卵巢癌的发生、发展中起重要作用;Smac有望成为治疗卵巢癌的新靶点。
Objective：To investigate the expression of Smac in epithelial ovarian carcinomas and its clinical significance.Methods：The expression of Smac proteins was detected with immunohistochemistry.Results： The positive expression rate of Smac in ovarian carcinomas was significantly lower than that in benign ovarian tumors and normal ovaries.Conclusion： Smac plays important roles in the occurrence and development of epithelial ovarian cancer,which may become new targest of epithelial ovarian cancer treatment.
出处
《现代肿瘤医学》
CAS
2012年第11期2379-2381,共3页
Journal of Modern Oncology
基金
陕西省卫生厅科研基金项目(编号:2010H14)
