摘要
目的:探讨丹参酮分散片的制备工艺。方法:采用正交设计法,以崩解时限、体外溶出度及混悬性为指标,对丹参酮分散片处方进行筛选。结果:分散片在30s内完全崩解,均匀性试验能通过710μm筛网,达到《英国药典》（1993年版）关于分散片的要求,体外溶出度明显优于普通片。结论:制备的丹参酮分散片工艺成熟,质量稳定。
OBJECTIVE: To study the preparation technique of tanshinone dispersible tablets.METHODS: Taking the disintegration time - limit, in vitro dissolubility and suspensibility as indices, the formula of tanshinone dispersible tablets was screened by orthogonal design.RESULTS The dispersible tablets could completely disintegrate within 30 seconds and pass through 710m seive mesh, which all conformed to the requiremtes of BP(1993) .The in vitro dissolubility of this product was superior to that of ordinary tablets obviously .CONCLUSION: The preparation technique of tanshinone dispersible tablets is mature and the quality is reliable.
出处
《中国药房》
CAS
CSCD
2002年第11期653-655,共3页
China Pharmacy
关键词
丹参酮
分散片
制备工艺
正交设计
Radix Salviae Miltiorrhizae
tanshinone
tanshinone II A
dispersible tablet
orthogonal design
