摘要
本课题研究了复方丹参液对30例慢性肺心病患者血浆脂质过氧化物(LPO)、红细胞超氧化物歧化酶(SOD)、全血谷胱甘肽过氧化物酶(GSH-px)和过氧化氢酶(CAT)活性的影响。结果:治疗前30例患者的LPO和SOD明显高于对照组(P<0.001和P<0.05),GSH-px、CAT明显低于健康对照组;治疗后丹参组4项指标均恢复到正常,而常规治疗组未能恢复正常;丹参组GSH-px和CAT的增加及LPO的降低明显大于常规组。说明丹参能明显降低慢性肺心病患者增强的脂质过氧化反应,纠正失衡的抗氧化物酶。
This paper studied the effect of Salvia miltiorrhiza(SM)on plasma lipid peroxidation(LPO),RBC superoxide dismutase(SOD),glutathione peroxidase(GSH-Px)and catalase.(CAT)activity in patients with chronic cor pulmonale.30 palients were rạndomly divided into two treatment groups(routine and SM).The four parameters have been measured in 22 healthy subjects as control and patients of two treatment groups.The results showed:(1)Before treatment both treatment groups had significantly higher LPO and SOD and markedly lower GSH-Px and CAT level than that of healthy control(P<0.001)respectively.(2)After treatment in routine group the four parameters have normalized,P<0.05.(3)Routine treatment was compared with SM,treatment,except SOD,the other three parameters were significantly different between two treatment groups(P<0.001).The increased levels of GSH-Px and CAT and the decreased LPO were significantly greater in SM group than routine treatment(P<0.001).The above-mentioned results indicated patients with cor pulmonale in acute exacerbation their lipid peroxide reaction was enhanced,the antioxidant enzymes lost their balance.SM could attenuate markedly lipid peroxide reaction,adjust the imbalance of the three antioxidant enzymes,enhance body's defence capability against damage of active oxygen free radical induced lipid peroxidation.
作者
张葡萄
陈真如
Zhang Pu-tao;Chen Zhen-ru(Nanjing Steel-works Hospital,Nanjing 210035)
出处
《中国中西医结合杂志》
CSCD
北大核心
1994年第8期474-477,共4页
Chinese Journal of Integrated Traditional and Western Medicine
关键词
丹参注射液
肺心病
过氧化脂质
Savia miltiorrhiza
chronic obstructive pulmonary disease
oxygen free radical
lipid peroxidation
superoxide dismutase
glutathione peroxidase
catalase
