摘要
目的分析比较齐拉西酮和利培酮治疗精神分裂症的疗效。方法将78例精神分裂症患者随机分为齐拉西酮组(A组,39例)和利培酮组(B组,39例)。A组患者予以齐拉西酮治疗,B组患者予以利培酮治疗。比较两组患者疗效,观察治疗前后精神分裂症状[阳性和阴性症状量表(PANSS)]评分、生活质量综合评定量表(GQOLI)评分变化,并记录不良反应发生情况。结果两组患者疗效及不良反应(体重增加、头晕、焦虑)发生率比较差异无统计学意义(P>0.05),A组患者锥体外系症状发生率低于B组(P<0.05)。治疗8周后,两组患者阳性量表分、阴性量表分、一般精神病理表分及PANSS总分均较治疗前降低(P<0.05),组间比较差异无统计学意义(P>0.05);两组患者GQOLI的物质生活、躯体功能、心理健康、社会功能4个维度评分均较治疗前升高(P<0.05),且A组高于B组(P<0.05或0.01)。结论齐拉西酮和利培酮均能有效改善精神分裂症患者症状,两者疗效相当,但服用齐拉西酮不良反应发生少,有利于患者生活质量的提高。
Objective To investigate and compare the curative effects of ziprasidone and risperidone in the treatment of schizophrenia.Methods78cases of schizophrenia were randomly divided into ziprasidone group(group A,39cases)and risperidone group(group B,39cases).The group A were given ziprasidone,and the group B were given risperidone.Then,curative effects of the two groups were compared,the scores of schizophrenic symptoms(positive and negative symptom scale,PANSS)and generic quality of life inventory(GQOLI)were observed before and after treatment,and the occurrence of adverse reactions was recorded.Results Difference of the incidence of the effects and adverse reactions(weight gain,dizziness and anxiety)between the two groups was not statistically significant(P>0.05),the incidence of extrapyramidal symptoms in the group A was lower than that in the group B(P<0.05).After8weeks of treatment,positive scale,negative scale,general psychopathology score and the total score of PANSS of the two groups were lower than those before treatment(P<0.05),difference between the two groups was not statistically significant(P>0.05).The scores of material life,body function,mental health and social function in GQOLI between the two groups of were all higher than those before treatment(P<0.05),and those of the A group were higher than those of the B group(P<0.05or0.01).Conclusion Both ziprasidone and risperidone can effectively improve the symptoms of schizophrenic patients,they have similar curative effects,but ziprasidone has fewer adverse reactions,which is conducive to the improvement of patients’quality of life.
作者
白由竹
裴晓媛
史金钟
申张恒
BAI Youzhu;PEI Xiaoyuan;SHI Jinzhong;SHEN Zhangheng(Psychiatric Department,The Fourth People’s Hospital of Jiaozuo,Jiaozuo 454000,China)
出处
《右江医学》
2017年第6期712-715,共4页
Chinese Youjiang Medical Journal
