摘要
目的用脑电超慢涨落分析仪(ET)探讨精神分裂症脑内神经递质变化及其与临床症状的关联性。方法用脑电超慢涨落分析仪提取在脑电中载有脑神经递质调节系统的震荡信息(即S谱线),分析精神分裂症患者和健康对照脑神经递质的活动情况,同时用阳性与阴性症状量表(PANSS)评估患者临床症状。结果与健康对照组相比,精神分裂症患者脑内γ-氨基丁酸(GABA)活动明显减弱(5.7±0.9和8.2±0.6,P<0.01),与兴奋因子呈负相关(r=-0.252,P<0.05);5-羟色胺(5-HT)(21.7±2.2和19.9±1.3,P<0.01)和多巴胺(DA)(10.8±1.2和6.8±1.2,P<0.01)活动明显增强,5-HT活动与阴性因子(r=0.291,P<0.05)、认知因子(r=0.348,P<0.01)呈正相关,DA活动与阳性因子呈正相关(r=0.293,P<0.05)。结论精神分裂症患者脑内GABA、5-HT和DA活动异常,通过复杂的机制导致了其各个特征性症状群。
Objective To investigate the correlation between the neurotransmitters activities and clinical symptoms in patients with schizophrenia with encephaloflucgram technology（ET）. Methods ET was used to extract shocking information from neurotransmitter regulation systems in EEG （S spectral line）, and the characteristics of neurotransmitters activities were analyzed both in patients with schizophrenia and normal controls. Furthermore, the clinical symptoms of the patients were evaluated by positive and negative syndrome scale （PANSS）. Results Compared with the normal control group, the activity of γ-aminobutyric acid（GABA） was significantly weakened （5.7±0.9 vs 8.2±0.6, P0.01） and negatively associated with excitation factors （r=-0.252, P0.05） in schizophrenia group. Moreover, the activities of serotonin （5-HT） （21.7±2.2 vs 19.9±1.3, P0.01） and dopamine （DA） （10.8±1.2 vs 6.8±1.2, P0.01） were obviously enhanced in schizophrenia group. Notably, the activity of 5-HT was positively associated with negative factors （r=0.291, P0.05） and cognitive factors, while DA was positively associated with positive factors （r=0.293, P0.05）. Conclusion There were abnormalities of GABA, 5-HT and DA activities in patients with schizophrenia, which might lead to various characteristic syndromes through complex mechanisms.
出处
《中国药物与临床》
CAS
2012年第4期413-415,共3页
Chinese Remedies & Clinics
基金
国家自然科学基金(81000583)
