摘要
目的 观察射频消融治疗肝肿瘤的疗效并探讨其评价方法。方法 采用射频消融治疗兔肝VX2肿瘤,观察肿瘤完全坏死率、病理改变、CT表现及动物生存时间。结果（1）ALT在射频消融（radio frequency ablation,RFA）治疗后第 1天明显升高 （124.7±27.1）U/L,4～7d降到治疗前的水平以下（46.8±13.1）U/L。（2）治疗后第2周,完全坏死的肿瘤CT示病灶范围稍扩大,其内密度不均,增强扫描显示病灶内无明显强化,但其边缘可出现环状强化带,活体观察见暗灰色的坏死组织被形状规则、呈环状生长的肉芽组织环绕;而RFA治疗后未完全坏死的肿瘤病灶CT平扫与完全坏死者类似,但增强扫描显示病灶内有不规则强化区域,活体观察显示坏死灶周围与正常肝脏之间增生的组织形状不规则,病理活检结果为肿瘤复发。（3）与对照组相比,治疗组平均生存时间明显延长,肺转移率及病死率也明显降低。结论RFA对肝肿瘤的治疗效果确切可靠,对肝功能的损伤小;RFA治疗后CT增强扫描与病灶的病理形态学表现有较好的一致性,是RFA治疗后观察肿瘤消融结果有价值的检查手段。
Objective To explore and evaluate the effect of radio frequency ablation(RFA) in treatment of hepatic VX2 tumor in rabbits. Methods The hepatoma was treated with RFA in rabbits. The complete necrotic rate of the tumors, pathological changes, CT images and the animals' survival time were observed. Results (1)ALT in serum increased significantly on the first day and decreased to the control level during 4th-7th day following RFA. (2)On the second week, CT scans showed that complete necrotic foci became larger, and the density of which was asymmetrical. Enhanced CT scans showed no obvious intensification inside; however, ringed intensification appeared along edges of the foci. Biopsy showed that the dark necrotic tissue was surrounded by ringed granulation tissue. Incomplete necrotic tumor foci resembled the complete necrotic foci in no enhanced CT images; however, asymmetrical intensification was observed in enhanced CT scans in the incomplete necrotic foci. Macroscopic observation showed irregular tumor tissue between the necrotic tissue and the peripheral normal tissue. Biopsy showed tumor recurrence in it. (3)Compared with the control, survival time of the animals was longer, and metastases rate in lungs and the fatality rate were lower in the treatment group. Conclusions RFA, with little injury, is an effective method in the treatment of hepatoma. Enhanced CT scans are consistent with pathological morphometrics of the tumor foci after RFA. The enhanced CT scan is a valuable check-up, which could be used to observe the therapeutic effect after RFA.
出处
《中华肝脏病杂志》
CAS
CSCD
2002年第5期362-365,共4页
Chinese Journal of Hepatology
关键词
射频消融术
治疗学
评价
CT表现
动物实验
肝细胞肿瘤
Carcinoma, hepatocellular
Radio frequency ablation
Therapeutics
Evaluation studies
Rabbits
