摘要
目的观察兔VX2射频消融后残余肿瘤模型不同时间段病理形态学变化。方法超声引导经皮穿刺48只新西兰白兔接种VX2肿瘤,并开腹射频消融制作残余肿瘤模型。将模型随机分成6组,每组8只,分别于射频消融术(RFA)之前、术后1天、3天、1周、2周及3周观察病理学变化。结果残余肿瘤组织射频消融术后MVD、VEGF及PCNA表达即明显减低,一直维持较低水平至射频消融后2周;RFA后2周至第3周,MVD、VEGF及PCNA表达再次增加。结论射频消融治疗后残余肿瘤短期内受到抑制,仍需要进一步治疗。
Objective To establish rabbit model of remnant carcinoma after RFA therapy, and to observe pathomorphological changes of remnant carcinoma in different time. Methods Forty-eight New Zealand white rabbits underwent ultrasoundguided percutaneous inoculation with VX2 carcinoma, then RFA therapy was performed to made models of remnant carcinoma. These models were averagely divided into 6 groups randomly （each n=8）. Rabbits in each group was killed and pathologically observed before RFA and 1 d, 3 d, 1 week, 2 and 3 weeks after operation, respectively. Results The expression of MVD,VEGF and PCNA in remnant VX2 carcinomas tissues decreased significantly, but increased 2-3 weeks after RFA. The remnant VX2 carcinomas tissues were in inhibitory state 2 weeks after RFA. Conclusion The growth of remnant carcinoma could be inhibited in short term after RFA. Further therapy is necessary.
出处
《中国医学影像技术》
CSCD
北大核心
2009年第10期1753-1756,共4页
Chinese Journal of Medical Imaging Technology
基金
黑龙江省科技厅青年基金(QC08C06)
黑龙江省教育厅科学技术研究(面上)项目计划(11541221)
关键词
导管消融
模型
动物
残余肿瘤
Catheter ablation
Models, animal
Remnant carcinoma
