摘要
目的 :观察甘油所致急性肾功能衰竭 (ARF)大鼠血浆降钙素基因相关肽 (CGRP)、一氧化氮 (NO)和内皮素 (ET)的变化及钙通道阻滞剂 (CCB)氨氯地平对其的影响。 方法 :检测正常和甘油所致 ARF大鼠不同时间血浆 CGRP、ET和血清NO水平的变化 ,并观察应用氨氯地平对肾脏功能及血浆 CGRP、ET和血清 NO的影响。 结果 :甘油所致 ARF大鼠血浆CGRP、NO水平明显降低 (P<0 .0 1,P<0 .0 5 ) ;血浆 ET明显升高 (P<0 .0 5 ) ,氨氯地平治疗组肾损害减轻 (P<0 .0 5 ) ,CGRP、NO显著升高 (P<0 .0 1,P<0 .0 5 )而 ET明显降低 (P<0 .0 5 )。 结论 :CGRP、NO的降低和 ET的升高可能参与甘油所致 ARF的形成和进展 ,氨氯地平对肾脏功能保护作用可能与其升高 CGRP、NO和降低 ET有关。
Objective: To investigate plasma calcitonin gene-related peptide (CGRP), endothelin(ET) and serum nitric oxide (NO) levels in rats with glycerol-induced acute renal failure (ARF) and effect of amlodipine on them. Methods: Plasma CGRP,ET and serum NO levels of glycerol-induced ARF rats with or without treatment with amlodipine were measured. Results: Plasma CGRP and serum NO levels of ARF rats decreased and plasma ET increased. Treatment with amlodipine improved the kidney injuries. Plasma CGRP and serum NO levels increased significantly (P<0.01,P<0.05) and plasma ET markedly decreased(P<0.05). Conclusion: Decreased plasma CGRP,NO and increased ET may play a role in the development of glycerol-induced ARF. The protection of amlodipine on renal function may be through the increase of CGRP,NO and the decrease of ET.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
2002年第9期1011-1013,共3页
Academic Journal of Second Military Medical University
