摘要
研究降钙素基因相关肽(CGRP)、神经肽y(NPY)与醛固酮(ALD)在门脉高压症发病中的作用。方法:应用放射免疫学方法对30例门脉高压症患者、30名正常对照者的血浆以及20例门脉高压症患者的腹水进行CGRP、NPY与ALD的检测。结果:门脉高压症组患者血浆CGRP、NPY与ALD水平分别为125.95±35.43pg/ml、88.49±52.51pg/ml及868.5±459.6pg/ml,正常对照组分别为69.14±23.29pg/ml、151.54±38.51pg/ml及306.4±124.3pg/ml,两组差别有显著意义(P<0.05),腹水组分别为81.83±38.55pg/ml、61.47±28.35pg/ml及216.7±186.1pg/ml。腹水CGRP与正常对照组相比差异无显著意义,腹水NPY与ALD含量低于正常对照组(P<0.05)。其中有腹水者NPY低于无腹水者,而CGRP与ALD水平高于无腹水者(P<0.05)。结论:血浆CGRP、NPY与ALD均在肝硬变门脉高压发病的病理生理机制中起作用。
To study the effects of calcitonin gene-related peptide (CGRP), neuropeptide Y (NPY) and aldos-
terone(ALD) in patients with portal hypertension. Methods:The level of 30 hematoplasma of patients with portal hypertension and 20 of their ascites were assayed by radioimmunoassay (RIA). the level of 30 hematoplasma of normal control were determinded at the sametime. Results: The level of CGRP, NPY and ALD in patients with portal hypertension were 125. 95±35. 43pg/ml, 88. 49±52. 51pg/ml and 868. 5±459. 6pg/ml, respectively. The levels in normal control were 69. 14±23.29pg/ml, 151. 54±38. 51pg/ml and 306. 4±124. 3pg/ml, respectively. The levels in ascites were 81.83±38. 55pg/ml, 61. 47±28. 35pg/ml and 216. 7±186. 1pg/ml, respectively. The level of NPY in patients was lower than that of normal control (P<0. 05), while the level of CGRP and ALD were higher than that of normal control (P< 0. 05);the level of NPY in patients with ascites was lower than that of without ascites, while the level of CGRP and ALD were higher than that of without ascites. Conclusion; CGRP, NPY and ALD play an important role in the pathogenesis of portal hypertension.
出处
《中西医结合肝病杂志》
CAS
2000年第6期7-11,共5页
Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases
基金
福建省自然科学基金项目(No:C96042)
关键词
门脉静永压
肝硬变
降钙素基因相关肽
神经肽y
Portal Hypertension Liver Cirrhosis Calcitonin Gene-Related Peptide (CGRP) Neuropeptide Y (NPY) Aldosterone (ALD)
