摘要
目的:探究雷公藤多苷联合维胺酯对银屑病患者免疫指标、内皮、炎性反应、sICAM-1及NF-κB的影响。方法:选择我院112例银屑病患者,随机分为对照组(n=56)和观察组(n=56)。对照组仅通过维胺酯胶囊进行治疗,观察组在对照组基础上联用雷公藤多苷片进行治疗,比较两组患者治疗前后免疫、内皮、炎性反应、可溶性细胞间黏附分子-1(sICAM-1)及核转录因子-kB(NF-κB)表达水平的变化。结果:治疗前,两组CD4^+、CD8^+、CD4^+/CD8^+、血管内皮生长因子(VEGF)、一氧化氮(NO)、内皮素-1(ET-1)、肿瘤坏死因子(TNF-α)、干扰素-γ(IFN-γ)、NF-κB及sICAM-1无显著性差异(P>0.05)。治疗后,两组CD4^+及CD4^+/CD8^+均较治疗前显著增加(P<0.05),而CD8^+较治疗前显著降低(P<0.05),观察组CD4^+及CD4^+/CD8^+均较对照组显著增加(P<0.05),而CD8^+较对照组显著降低(P<0.05);两组VEGF、NO及ET-1均较治疗前显著降低(P<0.05),观察组VEGF、NO及ET-1均较对照组显著降低(P<0.05);两组TNF-α及IFN-γ均较治疗前显著降低(P<0.05),观察组TNF-α及IFN-γ均较对照组显著降低(P<0.05);两组NF-κB及sICAM-1均较治疗前显著降低(P<0.05),观察组NF-κB及sICAM-1均较对照组显著降低(P<0.05)。结论:雷公藤多苷联合维胺酯胶囊治疗银屑病患者,可显著纠正其免疫功能紊乱、改善内皮功能、降低炎症反应及抑制NF-κB及sICAM-1表达水平。
Objective：To explore the effects of Tripterygium wilfordii combined with vitamin A on psoriasis patients’immune indexes,endothelium,inflammatory reaction,sICAM-1 and NF-κB.Methods：A total of 112 patients with psoriasis admitted in our hospital from September 2015 to November 2017 were randomly divided into control group （n=56） and observation group （n=56）.The control group was treated only by viaminate capsules,and the observation group was treated with Tripterygium wilfordii tablet on the basis of the control group,the immune,endothelial,inflammatory response,soluble intercellular adhesion molecules-1（sICAM-1） and nuclear factor-kB （NF-κB） expression levels were compared before and after treatment in the two groups.Results：Before treatment,two groups of CD4~＋,CD8~＋,CD4~＋/CD8~＋,vascular endothelial growth factor（VEGF）,nitric oxide（NO）,endothelin-1（ET-1）,tumor necrosis factor-α（TNF-α）,interferon-γ（IFN-γ）,NF-κB,and sICAM-1 were no significant difference（P〉0.05）.After treatment,two groups of CD4~＋ and CD4~＋/CD8~＋ were significantly increased（P〈0.05）,while CD8~＋ was significantly lower than before treatment（P〈0.05）,the CD4~＋ and CD4~＋/CD8~＋ in the observation group were significantly higher than those in the control group（P〈0.05）,and CD8~＋ was significantly lower than that of the control group（P〈0.05）;The two groups of VEGF,NO and ET-1were significantly lower than those before treatment（P〈0.05）,and the VEGF,NO and ET-1 in the observation group were significantly lower than those in the control group（P〈0.05）;The two groups of TNF-αand IFN-γwere significantly lower than before treatment（P〈0.05）,and TNF-αand IFN-γin the observation group were significantly lower than those in the control group（P〈0.05）;The two groups of NF-κB and sICAM-1 were significantly lower than those before treatment（P〈0.05）,and the NF-κB and sICAM-1 in the observation group were significantly lower than those in the control group（P〈0.05）.Conclusion：Tripterygium wilfordii combined with viaminate capsules in the treatment of psoriasis patients can significantly correct their immune dysfunction,improve endothelial function,reduce inflammatory response and inhibit the expression of NF-κB and sICAM-1 expression.
作者
刘婷
牟韵竹
刘艳
王理
LIU Ting;MOU Yun-zhu;LIU Yan;WANG Li(Department of Dermatology,Affiliated Hospital of North Sichuan Medical College,Nanchong 637000,China)
出处
《海南医学院学报》
CAS
2018年第17期1615-1618,1622,共5页
Journal of Hainan Medical University
基金
四川省卫生厅科研课题(100141)
川北医学院苗圃基金(MP-ZK-34)~~
