摘要
目的:检测关节病型银屑病患者外周血中VEGF水平的改变,探讨其与PASI评分、治疗前后的关系。方法:采用双抗体夹心酶联免疫技术(ELISA)检测23例关节病型银屑病患者治疗前、中、治疗后血清中VEGF水平。另检测了23例正常人血清中的VEGF水平作为对照组。结果:关节病型银屑病患者血清中VEGF水平较正常对照组显著增高(P<0.001),治疗前后患者血清中VEGF水平有显著差异(P<0.05)。结论:VEGF在关节病型银屑病发病机制中起重要作用。
Objective：The changes of serum vascular endothelial growth factor VEGF levels in psoriasis arthropathica were measured, and the relationship among cytokins, PASI and treatment were studied. Methods： Levels of VEGF in sera was measured by double antibody sandwich enzyme- linked immunosorbent assay （ELISA） in patients with psoriasis arthropathica before and after treatment and normal controls. Results： Serum levels of VEGF were significantly increased in patients with psoriasis arthropathica as compared with normal controls （ P 〈 0. 001 ） , and there was significant differenee between two groups of before and after treatment（ P 〈 0.05 ）. Conclusions： The VEGF may be very important to the pathogenesis of psoriasis arthropathica.
出处
《岭南皮肤性病科杂志》
2005年第3期202-204,共3页
Southern China Journal of Dermato-Venereology
关键词
银屑病
血管内皮生长因子
外周血
关节炎性
Psoriasis
Vascular endothelial growth factor
Peripheral blood
Arthritis
