摘要
目的:观察槐耳颗粒联合吡柔比星介入治疗乙型肝炎病毒(HBV)DNA阴性的乙肝肝癌患者的临床疗效并记录其不良反应。方法:选取2012年2月至2016年2月(随访时间为1年)在中国医科大学附属第一医院肝胆外科住院符合临床研究标准的HBV DNA阴性的肝癌患者120例(完成临床研究且临床资料数据可靠的96例),随机分为干预组与对照组,每组60例。对照组给予介入治疗(盐酸吡柔比星+超液化碘油)+替恩卡韦(抗病毒治疗)+常规保肝治疗;干预组在对照组的基础上给予槐耳颗粒治疗,2组均连续治疗6个月。治疗后比较2组的临床疗效、HBV DNA定量、肝酶、免疫学指标。结果:治疗后干预组近期及远期临床疗效均优于对照组(P<0.05),治疗前2组的肝酶、HBV DNA定量、免疫学指标差异无统计学意义(P>0.05),治疗后2组的肝酶、HBV DNA定量较治疗前有所降低(P<0.05),且干预组低于对照组(P<0.05),治疗后2组的免疫学(细胞免疫、体液免疫)指标均优于治疗前(P<0.05),且干预组优于对照组(P<0.05)。2组治疗中均出现白细胞降低、血小板计数降低、恶心、呕吐等不良反应。结论:槐耳颗粒联合介入治疗能很好的提高乙肝肝癌的临床疗效,且不良反应少。
Objective： To observe the clinical efficacy of Huaier granule combined with interventional treatment on patients with HBV DNA-negative Hepatitis B and record the adverse reaction.Methods： A total of 120 liver cancer patients with HBV DNAnegative Hepatitis B were randomly divided into intervene group and control group,with 60 patients in each group.Control group received intervention,percutaneous puncture of femoral artery,then injected Pirarubicin hydrochloride for injection ＋ lipiodol in parent artery until blood stagnation ＋ antivirus（ entecavir）,and also conventional liver protection therapy was conducted; intervene group additionally received Huaier granule for continuous 6 months.Clinical efficacy,HBV DNA quantification,and liver function indexes in the two groups were compared.Results： After treatment,short and long-term clinical efficacy in observation group was significantly better than the control group（ P〈0.05）.Before the treatment,there were no significant differences in HBV DNA quantification and liver function（ P〈0.05）.After treatment,the HBV DNA quantification and liver function were both lower than before treatment in both groups（ P〈0.05）,and the HBV DNA quantification and liver function were lower in the intervene group than control group（ P〈0.05）.After treatment,the cell-mediated immunity and humoral immunity were both better than before treatment in both groups（ P〈0.05）,and the cell-mediated immunity and humoral immunity were better in the intervene group than control group（ P〈0.05）.During the treatment,reducing leucocyte and platelet,nausea,vomit,etc.were occuring in both groups.Conclusion： Huaier granule combined with interventional treatment on patients with HBV DNA-negative Hepatitis B can improve the clinical efficacy,with less side effects.
作者
王冠蕾
富大智
王本刚
Wang Guanlei;Fu Dazhi;Wang Bengang(Department of Thoracic Surgery,The First Affiliated Hospital of China Medical University,Shenyang 110001,China)
出处
《世界中医药》
CAS
2018年第7期1597-1600,共4页
World Chinese Medicine
基金
辽宁省科学技术基金(20170541001)
关键词
槐耳颗粒
介入治疗
乙型肝炎
肝癌
临床疗效
Huaier granule
Interventional treatment
Hepatitis B
Liver cancer
Clinical efficacy
