摘要
本文对6名健康人一次静脉注射氨茶碱注射液(剂量5mg/kg),用UV法测其血药浓度的经时变化。其一定模型药物动力学参数为:t_(1/2)8.4730±2.733h;K0.08907±0.02846h^(-1);Vd0.4380±0.1809L/kg;Cmax13.2257±5.6220μg/ml。其中4名受试者唾液与血浆中茶碱浓度比率为0.5340±0.1407;7名受试者全血与血浆中茶碱浓度比率为0.7234±0.
Theophylline concentration was assayed by UV spectrophotometric method. Thepharmacokinetics of theopylline following intravenous injection of aminophyllinewere determined in six healthy adults. The parameters were calculated by a one-compartment model. The pharmacokinetic parameters calculated accordingly weret1/2 8.473±2.733h; K 0.08907±0.02846h^(-1); Vd 0.4380±0. 1809L/kg; Cmax 13.2257±5.622μg/ml.In 4 of 6 subjects the ratio of theophylline concentration insaliva an pla-sma was 0. 5340±0. 1407. In 7 subjects the ratio of theophylline concentration inwhole blood and plasma was 0.7234±0.08016.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
1991年第6期257-259,共3页
Chinese Journal of Hospital Pharmacy
关键词
比色法
茶碱
血药浓度
唾药浓度
spectrophotometric method
theophylline
plasma concentration
saliva concentration
pharmacokinetics
