摘要
本文报告用紫外分光光度法监测茶碱血药浓度(C)及唾药浓度(S),采用血清或唾液茶碱回收曲线计算,回收率稳定。测定30例病人口服氨茶碱0.1q8h后稳态茶碱C,峰值<10μg.ml者占90%,测定30例次病人的稳态茶碱C与S,两者相关性非常显著(C=1.53S+1.54,r=0.97,P<0.001),S/C=0.551±0.065(CV11.9%)。本文还分析讨论了口服氨茶碱常规给药方案,认为0.2q8h可对多数病人适用。
This paper reports the mornitoring of sereum concentration (C) and saliva concentration (S) of theophylline by UV. Calculat-ed with sereum or saliva thephylline regression curve, the rates of recovery were satisfactory. It was not influenced by theo-phylline concentrations. Theophylline C were detected in 30 patients after taking aminophylline 0.1g q8h orally About 90% oftheir peack concentrations were below 10μg/ml. Theophylline C and S in 30 patients or times were also tested. It showed a re-markable correlativity between them (c=1.53S+1.54, r=0.97, P<0.001), S/C=0.551±0.065 (CV 11.9%). The rou-tine administration schedule for taking aminophylline orally was also discussed that was 0.2q8h for most of patients.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
1992年第6期260-262,共3页
Chinese Journal of Hospital Pharmacy
关键词
氨茶碱
血药浓度
唾药浓度
监测
theophylline
blood concentration
salivery concentration
TDM
administration schedule
