摘要
盐酸洛美沙星由2,3,4-三氟硝基苯经还原、缩合环合、乙基化、螯合、与哌嗪缩合、水解成盐等六步反应制得。工艺简便,反应条件温和,总收率达40%。
A facile preparation of lomefloxacin hydrochloride(1),startingfrom 2,3,4-trifluoronitrobenzene,via reduction,condensation-cyclization,ethyla-tion,chelation,piperazination,hydrolysis,etc,was described.The reactions of allsteps were carried out in very moderate conditions to afford overall yield of 40%.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
1991年第10期437-439,共3页
Chinese Journal of Pharmaceuticals
关键词
洛美沙星
抗菌素
氟喹诺酮类
合成
lomefloxacin
fluoroquinolone antimicrobial agent synthesis
