摘要
目的观察腰痛宁胶囊联合醋酸曲安奈德注射液穴位注射治疗腰椎骨性关节炎的临床疗效。方法选取2016年5月—2017年1月铜仁市人民医院骨科收治的腰椎骨性关节炎患者52例为研究对象,按照住院日期单复数随机分为对照组和治疗组,每组各26例。对照组给予穴位注射治疗,醋酸曲安奈德注射液4 mL和2%利多卡因4 mL加入到0.9%氯化钠注射液12 mL中,取上清10 mL,分别在肾俞、委中、昆仑、太溪、足三里、夹脊穴位处进针,3~4 mL/穴位,1次/3 d。治疗组在对照组的基础上睡前口服腰痛宁胶囊,4~6粒/次,1次/d。两组患者均连续治疗4周。观察两组的临床疗效,比较两组的VAS评分、JOA脊柱功能、一氧化氮(NO)和粒细胞–巨噬细胞集落刺激因子(GM-CSF)水平。结果治疗后,对照组和治疗组的总有效率分别为73.1%、88.5%,两组比较差异有统计学意义(P<0.05)。治疗后,两组VAS评分显著下降,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组VAS评分明显低于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组JOA脊柱功能评分均明显提高,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组JOA脊柱功能评分明显高于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组NO和GM-CSF水平均明显降低,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组这些观察指标明显低于对照组,两组比较差异具有统计学意义(P<0.05)。结论腰痛宁胶囊联合醋酸曲安奈德注射液穴位注射治疗腰椎骨性关节炎具有较好的临床疗效,可改善腰椎关节功能,降低患者疼痛程度,调节NO和GM-CSF水平,具有一定的临床推广应用价值。
Objective To observe the clinical effect of Yaotongning Capsules combined with Triamcinolone Acetonide Acetate Injection in acupoint injection in treatment of lumbar osteoarthritis.Methods Patients（52 cases） with lumbar osteoarthritis in Department of Joint Surgery of Tongren People’s Hospital from May 2016 to January 2017 were randomly divided into control and treatment groups,and each group had 26 cases.Patients in the control group were given acupoint injection therapy,Triamcinolone Acetonide Acetate Injection（4 mL） and lidocaine（4 mL,2%） added into normal saline 12 mL,injected into the acupoints（shenshu,Venezuela,Kunlun,Zusanli,Taixi,and Jiaji）,3 — 4 mL/acupoint,1 time every 3 days.Patients in the treatment group were po administered with Yaotongning Capsules before going to bed on the basis of the control group,4 — 6 grains/time,once daily.Patients in two groups were treated for 4 weeks.After treatment,the clinical efficacies were evaluated,and VAS scores,JOA spinal function scores,NO,and GM-CSF levels in two groups were compared.Results After treatment,the clinical efficacies in the control and treatment groups were 73.1% and 88.5%,respectively,and there was difference between two groups（P 〈 0.05）.After treatment,the VAS scores in two groups were significantly decreased,and the difference was statistically significant in the same group（P 〈 0.05）.And the VAS score in the treatment group were significantly lower than those in the control group,with significant difference between two groups（P 〈 0.05）.After treatment,the JOA spinal function scores in two groups were significantly increased,and the difference was statistically significant in the same group（P 〈 0.05）.And the JOA spinal function score in the treatment group were significantly higher than those in the control group,with significant difference between two groups（P 〈 0.05）.After treatment,the levels of NO and GM-CSF in two groups were significantly decreased,and the difference was statistically significant in the same group（P 〈 0.05）.And the observational indexes in the treatment group were significantly lower than those in the control group,with significant difference between two groups（P 〈 0.05）.Conclusion Yaotongning Capsules combined with Triamcinolone Acetonide Acetate Injection in acupoint injection has clinical curative effect in treatment of lumbar osteoarthritis,can improve the function of lumbar joint,reduce the pain degree of patients,and adjust the level of NO and GM-CSF,which has a certain clinical application value.
出处
《现代药物与临床》
CAS
2017年第11期2226-2230,共5页
Drugs & Clinic
