摘要
目的研究一氧化氮与骨性关节炎发病的关系。方法抽取骨性关节炎和类风湿性关节炎患者的关节积液和血清，及关节镜下清理术中切除的骨性关节炎滑膜和退变软骨作为标本，用硝酸还原酶法测定其中的一氧化氮含量并进行比较。结果骨性关节炎患者的软骨及滑膜中一氧化氮含量明显高于其血清及关节液，且软骨中一氧化氮含量明显高于滑膜。类风湿性关节炎患者关节液中一氧化氮浓度明显高于其血清及骨性关节炎的关节液。结论骨性关节炎患者的软骨及滑膜中一氧化氮含量明显升高，可能引起其自身组织损伤，而成为关节软骨退变和滑膜炎症的病因之一。类风湿性关节炎关节液中一氧化氮浓度明显高于骨性关节炎可为这两种疾病的鉴别提供依据，同时也提示虽同为一氧化氮引起的组织损伤，但其发病机制不同。
Objective To investigate the relationship between Nitric Oxide (NO) and the pathogenesis of osteoarthritis (OA). Methods The synovial fluid and serum taken from the patients with OA andrheumatoid athritis(RA), and the synovium and hyperplastic cartilage taken from the patients with OA througharthroscope were used to detect the NO concentration by the method of Nitric acid reductase and the valuesobtained in the OA and RA groups were compared. Results The NO contents of the cartilage and synoviumin OA were markedly higher than that of synovial nuid and serum, the content in the cartilage was obviouslyhigher than that in the synovium. The synoviual fluid NO concentration in RA was dramatically higher thanthat in the serum and synovial fluid in OA. condusion In OA patients, the NO contents markedly increased in cartilage and synovium, this might cause damage of their own tissue and cause the edicular car-tilage breakdown and the iaflammation of synovium. It might serve as an indicator to distingUish OA from RA,the NO concentration of synovial fluid in RA patients is dramatically higher than that in OA patients, and alsoindicate that although the NO causes the same injury of the tissue but the mechanism of disease was different inOA and RA.
出处
《中华骨科杂志》
CAS
CSCD
北大核心
1999年第7期411-414,共4页
Chinese Journal of Orthopaedics
