摘要
目的:分析复方紫荆消伤巴布膏治疗软组织损伤发生不良反应的影响因素。方法:选择2015年12月至2017年7月在上海中医药大学附属曙光医院等11家医院就诊,且采用复方紫荆消伤巴布膏治疗的软组织损伤患者的病例资料。采集相关信息并判断不良反应,统计不良反应发生情况,分析不良反应发生的影响因素。结果:共纳入符合要求的软组织损伤患者2380例,不良反应分析结果显示,14例发生不良反应,其中13例发生皮肤过敏反应,表现为红肿、瘙痒等症状,1例胸肋部疼痛加剧。发生不良反应的患者和未发生不良反应的患者,性别、治疗时间、合并用药、损伤类型比较,组间差异均无统计学意义(χ^(2)=0.341,P=0.559;χ^(2)=1.502,P=0.472;χ^(2)=0.103,P=0.749;χ^(2)=4.988,P=0.083)。结论:复方紫荆消伤巴布膏治疗软组织损伤发生的不良反应中以皮肤过敏反应较为常见,性别、合并用药、治疗时间、损伤类型均不是不良反应发生的影响因素。
Objective:To analyze the influencing factors of adverse drug reactions(ADRs)resulting from Fufang Zijing Xiaoshang Babugao(复方紫荆消伤巴布膏,FFZJXSBBG)for treatment of soft tissue injuries.Methods:The medical records of patients who were treated with FFZJXSBBG for soft tissue injuries in 11 hospitals including Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine from December 2015 to July 2017 were selected.The relevant information was collected and the ADRs were judged.The statistics on incidence of ADRs was carried out and the influencing factors of ADRs were analyzed.Results:Two thousand three hundred and eighty patients were included in the study.The results of ADRs analysis revealed that 14 patients suffered from ADRs including skin al-lergic reactions,manifesting as swelling and pruritus,in 13 patients and aggravated sternal rib pain in 1 patient.There was no statistical difference in gender,treatment time,drug combination and injury types between patients with ADRs and patients without ADRs(χ^(2)=0.341,P=0.559;χ^(2)=1.502,P=0.472;χ^(2)=0.103,P=0.749;χ^(2)=4.988,P=0.083).Conclusion:The skin allergic reaction is a common ADR resulting from FFZJXSBBG for treatment of soft tissue injuries,and none of gender,drug combination,treatment time and injury types are considered as the influencing factors of ADRs.
作者
杨琪
詹红生
杜炯
YANG Qi;ZHAN Hongsheng;DU Jiong(Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)
出处
《中医正骨》
2021年第4期20-21,27,共3页
The Journal of Traditional Chinese Orthopedics and Traumatology
