摘要
以3-吡啶乙酸盐酸盐与氨基硫脲为原料经环化反应制备中间体2-氨基-5-(3-吡啶亚甲基)-1,3,4-噻二唑,后者与取代苯甲酰氯反应合成了一系列含吡啶环的N-(1,3,4-噻二唑-2-基)取代苯甲酰胺(3a^3k),其结构通过IR、~1H NMR、^(13)C NMR、MS和元素分析确证。用菌丝生长速率法测定了目标化合物对灰霉菌的离体抑菌活性,结果表明,部分化合物对病原菌有一定的抑制活性。
The intermediate 2-amino-5-（ 3-pyridinylmethyl）-1,3,4-thiadiazole was prepared from 3-pyridinylacetic acid hydrochloride and thiosemicarbazide by cyclization,followed by reaction with substituted benzoyl chloride to yield the target compound,N-[5-（ 3-pyridylmethyl）-1,3,4-thiadiazol-2-yl]benzamides（ 3a ~ 3k）. Their structures were elucidated by IR,~1H NMR,^（13） C NMR,MS and elemental analysis. Meanwhile,the target compounds were evaluated for their antifungal activities against B. cinerea by the mycelium growth rate method,and the results indicated that some compounds display antifungal activity to some extent.
出处
《化学通报》
CSCD
北大核心
2017年第9期868-872,共5页
Chemistry
基金
山东省自然科学基金项目(ZR2014BM030)资助
关键词
吡啶
噻二唑
酰胺
合成
抑菌活性
Pyridine
Thiadiazole
Amide
Synthesis
Antifungal Activity
