摘要
为了发现高效、低毒的农用先导化合物,本文采用活性亚结构拼接原理,设计并合成了一类含吡啶基查尔酮类化合物。初步抑菌活性测试结果表明,在测试浓度为100μg/m L时,大多数化合物对供试的水稻纹枯病菌(Rhizoctorzia solani)、苹果轮纹病(Physolospora piricola)、小麦赤霉病菌(Fusarium graminearum)、玉米小斑病菌(Bipolaris maydis)四种植物病原菌均具有一定的抑菌活性,其中化合物I9,I15和I16对水稻纹枯病菌的抑制率在90%以上。病原菌毒力测试表明,化合物I16的EC50值为35.43μg/m L,高于对照药多菌灵(40.56μg/m L)的值,此外,化合物I16还表现出了较宽的抑菌谱,其对四种植物病原菌的抑菌率均大于80%。
In order to find new anti-fungal leading compounds with high performance and low toxicity, this paper designed and synthesized a series of chalcone analogs with pyridyls according to a principle of splice. Bioassays showed that most of target compounds had a certain anti-fungal activities against Rhizoctorzia solani, Physalospora piricola, Fusarium graminearum and Bipolaris maydis at a dosage of 100 μg/mL. Inhibition rates of compounds I9, I15 and I16 were more than 90%. The EC50 value of compound I 16 was 35.43 μg/mL, which was higher than the control group Carbendazim（40.56μg/mL）. Furthermore, compound I16 showed a broad-spectrum fungicidal activity, its fungicidal rate against tour kinds of fungi were greater than 80%.
出处
《山东农业大学学报（自然科学版）》
CSCD
2016年第2期166-171,共6页
Journal of Shandong Agricultural University：Natural Science Edition
基金
国家自然科学基金(31272068)
关键词
吡啶基
查尔酮
合成
抑菌活性
Pyridyl
Chalcone
synthesis
anti-fungal activity
