摘要
采用HP20大孔吸附树脂、ODS、硅胶柱色谱、Sephadex LH-20柱色谱和半制备HPLC等色谱分离手段对紫花前胡的化学成分进行研究。结合理化性质及MS,NMR等谱学数据鉴定化合物的结构,从紫花前胡80%乙醇提取物中分离并鉴定了12个化合物,分别是(9R,10R)-9-acetoxy-8,8-dimethyl-9,10-dihydro-2H,8H-benzo[1,2-b:3,4-b']dipyran-2-one-10-yl ester(1)、补骨脂呋喃香豆精(2)、顺式-3',4'-二千里光酰基-3',4'-二氢邪蒿内酯(3)、(3'R,4'R)-3'-angeloyloxy-4'-senecioyloxy-3',4'-dihydroseselicalipteryxin(4)、(+)-8,9-dihydro-8-(2-hydro-xypropan-2-yl)-2-oxo-2H-furo[2,3h]chromen-9-yl-3-methylbut-2-enoate(5)、libanoridin(6)、丝立尼亭(7)、花椒素(8)、crocatone(9)、peujaponisinol B(10)、peujaponisinol A(11)、ostenol(12)。其中,化合物1~5为首次从当归属植物中分离得到,化合物7~12为首次从紫花前胡中分离得到。
The compounds were isolated and purified by HP20 macroporous adsorption resin, ODS, Silica gel, and Sephadex LH-20 column chromatography, as well as semi-preparative HPLC chromatography from the 80% ethanol extract of the root of Angelica decursi- va, and their structures were identified based on their physiochemical properties and spectroscopic data. Twelve compounds were struc- tures were identified as （ 9R, 10R） -9-acetoxy-8,8-dimethyl-9, 10-dihydro-2H, 8H-benzo [ 1,2-b ： 3,4-b＇ ] dipyran-2-one-10-yl ester （ 1 ）, bakuchicin （2）, （ 3＇, S, 4＇ S） -disenecioyloxy-3＇, 4＇-dihydroseselin （ 3 ）, （ 3＇ R, 4＇ R ） -3＇-angeloyloxy-4＇-senecioyloxy-3 ＇, 4＇-di- hydroseselincalipteryxin （4）, （ ＋ ） -8,9-dihydro-8-（ 2-hydroxypropan-2-yl ） -2-oxo-2H-furo [ 2,3h ] chromen-9-yl-3-methylbut-2-enoate （$）, libanoridin （6）, selinidin （7）, suberosin （8）, crocatone （9）, peujaponisinol S （10）, peujaponisinol A （11）, and ostenol （12）, respectively. Compounds 1-5 were isolated from the plants of Angelica genus for the first time. Compounds 7-12 were isolated from A. decursiva for the first time.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2017年第15期2999-3003,共5页
China Journal of Chinese Materia Medica
关键词
当归属
紫花前胡
香豆素
化学成分
Angelica
Angelica decursiva
coumarins
chemical constituents
