摘要
目的探讨FHIT蛋白在外阴癌发生发展过程中的作用。方法用免疫组化SP法对20例正常外阴、22例外阴上皮内瘤样病变(VINs)及60例外阴癌组织分别进行FHIT蛋白表达的检测。结果正常外阴组织、低级别VINs、高级别VINs、外阴癌FHIT蛋白阳性表达率分别为100%(20/20),72.7%(8/11),45.5%(5/11),21.7%(13/60),差异有统计学意义(P<0.05)。在高、中、低分化的浸润性外阴癌中,FHIT蛋白的阳性表达率分别为60.0%(9/15),20.0%(3/15),3.3%(1/30),差异有统计学意义(P<0.05);有淋巴结转移者FHIT蛋白阳性表达率为10.0%(2/20),明显低于无淋巴结转移者的27.5%(11/40)。结论FHIT蛋白的异常表达在外阴癌的发展中起着重要作用,而且可为外阴癌的预后提供重要的信息。
Objective To explore the relationship betweenthe reduction of FHIT expression of fragile histidine （FHIT） and the development of vulvar carcinoma. Methods The expression of the FHIT product was detected by immunochemistry in the tissue samples of 20 normal vulvas, 22 vulvar intraepithelial neoplasias （VINs）, and 60 primary vulvar carcinomas. Results The expressive rates of FHIT protein in the squamous epithelium of normal vulvas, VIN Ⅰ -Ⅱ , VIN Ⅲ, and noninvasive and invasive vulvar carcinoma were 100% （20/ 20）, 72. 70% （8/11）, 45. 5% （5/11）, and 21.7% （13/60） respectively （P 〈 0. 05）. The expressive rates of FHIT protein in the well differentiated, intermediately differentiated and poorly differentiated invasive vulav carcinoma were 60. 0%（9/15）, 20. 0%（3/15）, and 3. 3%（1/30） respectively （P〈0. 05）. The expressive rate of the impaired FHIT protein in the invasive vulva carcinoma with lymphnode metastasis （10%） was lower than that without lymphnode metastasis （27.5%）. Conclusion Abnormal FHIT expression may play an important role in the progression of vulvar carcinoma. The expression of FHIT may provide important information for the prognosis of vulva carcinoma.
出处
《四川大学学报（医学版）》
CAS
CSCD
北大核心
2006年第2期218-220,共3页
Journal of Sichuan University(Medical Sciences)
基金
四川省科技厅应用基础资金(04JY029-077-2)资助
