摘要
目的研究TSH抑制治疗对老年甲状腺癌患者术后骨代谢相关指标的影响。方法将医院收治的68例行手术治疗老年甲状腺癌患者纳入研究对象,按照术后治疗差异分为研究组(34例)与对照组(34例),研究组予以TSH抑制治疗,对照组予以TSH常规疗法,另取同期34例健康志愿者作为健康对照组,比较患者术后骨代谢相关指标情况。结果用药前,对照组与研究组FT3、FT4明显低于健康组,且两组TSH明显高于健康组(P<0.05);用药后,研究组FT3、FT4显著高于对照组,且TSH显著低于对照组(P<0.05);用药前后,三组钙、碱性磷酸酶、磷水平、骨密度比较均不具显著性差异(P>0.05)。结论常规剂量TSH能够维持老年甲状腺患者术后正常生理需求,TSH抑制治疗能让甲状腺功能处于亚临床甲亢状态,不会给患者骨代谢以及骨密度带来大的影响。
Objective To study the effect of thyroid stimulating hormone （TSH） suppressive therapy on bone metab- olism related indexes in elderly patients with thyroid cancer. Methods Sixty - eight elderly patients with thyroid cancer in our hospital were divided into the study group （ n = 34） and the control group （ n = 34）. The study group was treated by TSH suppressive therapy, and the control group was treated by TSH routine therapy. Another 34 healthy volunteers were selected as healthy control group to compare the bone metabolism related indexes. Results Before treatment, FI＇3 and FT4 in the control group and the study group were significantly lower than those in the healthy group, while TSH was significantly higher （ P 〈 O. 05 ）. After treatment, FF3 and FT4 in the study group were significantly higher than those in the control group, while TSH was significantly lower （P 〈 0.05 ）. Before and after treatment, calcium, alkaline phosphatase and phosphorus levels and bone mineral density showed no significant differences （P 〉 0. 05 ）. Conclusion Routine dose TSH can maintain normal physiological needs of elderly patients with thyroid cancer after operation. TSH suppressive therapy can make the thyroid func- tion in subclinical hyperthyroidism status, and will not significantly affect bone metabolism and bone mineral density in pa- tients.
出处
《现代医院》
2017年第2期241-244,共4页
Modern Hospitals
关键词
老年甲状腺癌
TSH抑制治疗
术后
骨代谢
影响
Elderly Patients with Thyroid Cancer
TSH Suppressive Therapy
Postoperative
Bone Metabolism
Effect
