摘要
目的分析患者甲状腺过氧化物酶抗体（TPOAb）和甲状腺球蛋白抗体（TGAb）水平与甲状腺癌的关系。方法选取2001年1月至2009年12月手术治疗的分化型甲状腺癌患者283例为研究组，同期结节性甲状腺肿患者500例为对照组，分析甲状腺自身抗体是否是甲状腺癌的危险因素。将甲状腺癌患者按有无淋巴结转移分组，比较两组间甲状腺自身抗体阳性率差异。结果多因素logistic回归分析与甲状腺癌相关的独立危险因素为肿物较小、TGAb升高和TSH升高。伴淋巴结转移的甲状腺癌患者TGAb阳性率明显高于无淋巴结转移患者（P〈0．05）。结论TGAb可能是与甲状腺癌相关的预测因子，在甲状腺癌患者中增高提示淋巴结转移可能。
Objective Retrospectively evaluation the relationship between thyroid cancer and serologic thyroid autoantibodies thyroid peroxidase antibody （TPOAb） and thyroglobulin antibody （TGAb）. Methods We retrospectively reviewed 283 patients of differentiation thyroid cancer from Jan 2001 to Dee 2009, and 500 nodular goiter patients were taken as control. Results On the multivariate analysis, decreased tumor size, elevation of TgAb and TSH were all significant independent factors for thyroid cancer. the occurrence of elevation of TgAb was significant higher in thyroid cancer patients with lymph node metastasis than those without （ P 〈 0.05 ）. Conclusion A positive serum TgAb test was an independent predictor for thyroid cancer and may be connected with lymph node metastasis.
出处
《中华实验外科杂志》
CAS
CSCD
北大核心
2011年第11期1986-1987,共2页
Chinese Journal of Experimental Surgery
