摘要
目的 制备水溶性槲皮素精氨酸复合物 (QAC) ,拓宽槲皮素的给药途径。方法 取一定量槲皮素 (QUE)和 L-精氨酸在乙醇中回流制备 QAC,通过胶束纸色谱 ,紫外吸收光谱、红外吸收光谱和 X射线衍射图谱对 QAC进行结构鉴定。结果 摩尔比为 1∶ 1的 QU E和 L -精氨酸形成了 QAC,并且 QAC常温下稳定存在。与 QUE比较 ,QAC的水溶性明显增大 ,仍然对抑制细胞生长具有较强的活性。结论 该制备方法简捷实用 ,有助于提高 QUE的生物利用度。
Object To prepare the water soluble quercetin arginine complex (QAC) and widen the administration path of quercetin (QUE). Methods Definite QUE and L arginine were refluxed in alcohol to prepare QAC. The QAC structure was identified by micellar paper chromatography, UV spectrometry, IR spectrometry, and X ray diffraction. Results QAC was prepared from QUE and L arginine in molar ratio 1∶1. The inhibitory activity of QAC that existed stably in room temperature on cancer cell growth was as strong as that of QUE, and the solubility of QAC in water was remarkably enhanced. Conclusion The above preparation method is simple and available, and it is suitable to improve the bioavailability.
出处
《中草药》
CAS
CSCD
北大核心
2002年第8期695-697,共3页
Chinese Traditional and Herbal Drugs
基金
广东省教育厅重点学科专项基金 (95 0 5 )
广东医学院科研基金 (XK980 3 )
