摘要
槲皮素为黄酮类化合物。兔iv槲皮素10m g·kg^(-1)后.血药浓度—时间曲线符合二室模型。T_(1/2)(α)为2.91 ±1.36min,T_(1/2)(β)183.78±82.67min,V_B为0.624±0.225 L·kg^(-1),CL为3.15±2.11 ml·kg^(-1)·min^(-1).槲皮素10mg·kg^(-1)ig后,生物利用度为42.7％,药峰浓度(C_(Dk))为10.9mg·L^(-1),药峰时间(t_(pk))为60min。iv槲皮素后.药物以原型和代谢产物两种形式经尿、胆汁排泄,消除较迅速。
The studies on pharmacoki-netics of Quercetin in rabbits were carried out by UV-spectrophotometry. The experimental results were shown that after 10mg · kg-1 of Quercetin iv administration in rabbits, the curve of plasma concentration - time was shown to fit an open two compartment model. The pharmacokinetic parameters were as follow:T1/2 (α) = 2. 91 ± 1. 36min,T1/2(β) = 183. 78±82. 67min,Vd=0. 624±0. 225L ???
kg-1,CL = 3. 15 ±2. llml · kg-1 · min-1. The bioavailability (F) of Quercetin after 10mg · kg-1 ig in rabbits was 42.7% and Cpk was 10. 9mg · L, tpk was 60min.
After 10mg · kg-1 iv administration in rabbits,Quercetin was rapidly eliminated from the blood. The compound and its metabolites were exereten by kidney and bile.
出处
《中国药理学通报》
CAS
CSCD
北大核心
1992年第6期452-455,共4页
Chinese Pharmacological Bulletin
关键词
槲皮素
分光光度法
药代动力学
Quercetin
UV - spec-trophotometriy
pharmacokinetics
