摘要
目的:考察不同pH条件下2-羟丙基-β-环糊精(HPCD)对丹皮酚的增溶作用及包合物的稳定常数。方法:在25℃运用相溶解度法进行增溶试验,采用紫外分光光度法测定丹皮酚的浓度。结果:随着HPCD浓度增加,丹皮酚的溶解度增加。在pH3及HPCD浓度为133.33mmol·L-1条件下,丹皮酚与HPCD形成的包合物表观稳定常数为1425,丹皮酚的溶解度可达到10mg·mL-1。结论:对于难溶性药物,丹皮酚是较理想的增溶剂。
Objective： To study the solubilization effect of 2-hydroxypropyl-β-cyclodextrin （HPCD） on paeonolum at various pH value. Method： Phase-solubility method was adopted to study the solubilization effect at 25℃ and UV spectrohotometer was used to determine paeonolum content. Results： The apparent solubility of paeonolum was significantly enhanced by increased HPCD concentration. The apparent stability constant of paeonolum compounds was calculated up to 1425 in which pH was 3 and HPCD concentration was 133.33 mmol·L^-1. The solubility of paeonolum came up to 10 mg·mL^-1. Conclusion： HPCD is an ideal solubilizer for paeonolum.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2005年第15期1154-1156,共3页
China Journal of Chinese Materia Medica
