摘要
目的:探讨低剂量阿米替林对复发性腹泻性肠易激综合征患者血清5-羟色胺(5-HT)、神经肽Y(NPY)的影响。方法:选取复发性腹泻性肠易激综合征患者86例,随机分为观察组与对照组两组,每组43例,对照组患者给予维生素C治疗,观察组患者在对照组治疗基础上给予低剂量阿米替林治疗,比较两组患者治疗有效率和治疗前后临床症状积分,分析低剂量阿米替林对复发性腹泻性肠易激综合征患者血清5-HT和NPY水平变化的影响。结果:观察组患者治疗总有效率为95.35%,与对照组(79.07%)相比,差异有统计学意义(P<0.05);治疗1周、4周及3个月后观察组临床症状积分与对照组相比,差异有统计学意义(P<0.05);观察组治疗后5-HT水平(85.78±16.84)ng/ml,与对照组(96.48±17.68)ng/ml相比,差异有统计学意义(P<0.05);观察组治疗后NPY水平(118.84±30.58)pg/ml,与对照组(141.32±28.66)pg/ml相比,差异有统计学意义(P<0.05)。结论:低剂量阿米替林治疗复发性腹泻性肠易激综合征能提高患者治疗有效率,降低患者血清5-HT和NPY水平,缓解患者腹痛与腹部不适,改善肠动力紊乱状况,有临床应用推广价值。
Objective To study the low dosage of amitriptyline in influencing the serum 5-HT and NPY of recurrent-diarrhea-type irritable bowel syndrome patients. Method 86 cases of recurrent-diarrhea-type irritable bowel syndrome patients treated were selected and randomly divided into observation group and contrast group with each group 43 cases. Patients in the contrast group were given vitamin C treatment,while patients in the observation group were given vitamin C combined with low dosage of amitriptyline treatment. The total effective rate and the clinical symptoms of before and of after treatment were compared and the influence of serum 5-HT and NPY of the recurrent-diarrhea-type irritable bowel syndrome patients between the two groups were analyzed. Results The total effective rate in the observation group was 95. 35% which was obviously higher than the contrast group＇s 79. 07%,the difference was statistically significant（ P〈0. 05）. In the observation group,the clinical symptoms of 1 week after treatment,of 4 weeks after treatment and of 3 months after treatment were respectively significantly lower than the contrast group,the difference was statistically significant（ P〈0. 05）. After treatment,the 5-HT level in the observation group was（ 85. 78 ± 16. 84） ng/ml which was obviously lower than the contrast group＇s（ 96. 48 ± 17. 68） ng/ml,the difference was statistically significant（ P〈0. 05）. And the NPY level in the observation group was（ 118. 84 ± 30. 58） pg/ml which was obviously lower than the contrast group＇s（ 141. 32 ± 28. 66） pg/ml,the difference was statistically significant（ P〈0. 05）. Conclusion Low dosage of amitriptyline is proved to be effective in treating recurrent-diarrhea-type irritable bowel syndrome patients. It helps to decrease the serum 5-HT and NPY levels,relieves the stomachache and abdominal discomfort and improves the intestinal dysmotility. Thus,it deserves to be widely promoted in the clinical field.
出处
《吉林医学》
CAS
2017年第1期67-69,共3页
Jilin Medical Journal
