小剂量阿米替林治疗84例难治性腹泻型肠易激综合征的时-效关系及长期疗效的资料分析被引量：6

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摘要难治性肠易激综合征（Refractory IBS）患者症状持续或反复发作,频繁就诊,常规治疗疗效不佳,严重影响生活质量和增加医疗费用,且多伴发焦虑抑郁情绪和睡眠障碍[1-2].近年国外学者发现小剂量三环类抗抑郁药阿米替林（Amitriptyline,AMT）治疗IBS有效,副作用低而于近年受到广泛重视[3],但迄今未见小剂量AMT治疗难治性腹泻型IBS（D-IBS）及其对患者自然病程影响的研究.本研究通过观察小剂量AMT治疗难治性D-IBS患者的时-效改变并开展为期1年的随访,旨在首次阐明小剂量阿米替林对难治性腹泻型IBS的中长期疗效以及撤药后复发率.

作者游乐卿贾林刘静石曼曼曼平丽黄耀星许鸣耿庆山

机构地区广州医科大学附属广州市第一人民医院消化内科广州市南沙中心医院广东省第二人民医院消化内科广东省卫计委

出处《中华行为医学与脑科学杂志》 CAS CSCD 北大核心 2014年第12期1105-1107,共3页 Chinese Journal of Behavioral Medicine and Brain Science

关键词难治性肠易激综合征腹泻型肠易激综合征常规治疗中长期疗效阿米替林小剂量时-效关系 IBS患者

分类号 R574 [医药卫生—消化系统]

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参考文献3

1刘彬彬,贾林,江舒曼,黄耀星,许鸣,王胜炳,耿庆山.广东地区难治性肠易激综合征患者抑郁焦虑状况的大样本、多中心调查[J].中华行为医学与脑科学杂志,2013,22(2):140-143. 被引量：20
2Roja Rahimi,Shekoufeh Nikfar,Ali Rezaie,Mohammad Abdollahi.Effi cacy of tricyclic antidepressants in irritable bowel syndrome:A meta-analysis[J].World Journal of Gastroenterology,2009,15(13):1548-1553. 被引量：22
3黄微,贾林,江舒曼,黄耀星,龚艳媚,王桂芹.小剂量阿米替林对健康志愿者胃肠功能影响的随机双盲交叉对照研究[J].中华消化杂志,2013,33(6):361-365. 被引量：5

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