摘要
Chromodomain helicase/ATPase DNA binding protein 1-like gene(CHD1L)是一种新发现的位于染色体1q21致癌基因,主要通过细胞增殖、G1/S期的转变、抑制凋亡、染色质不稳定等机制致癌,并被认为是影响癌症的进程、预后和生存率的独立标志物。CHD1L活化的潜在机制可能是通过与Parp1、凋亡蛋白Nur77结合破坏细胞死亡程序,或者通过介导目的基因ARHGEF9、TCTP、SPOCK1、NTKL发挥相应功能。文中主要介绍了CHD1L在癌症中的作用和相关分子机制的研究进展。
CHD1L is a newly identified oncogene located at Chr1q21,its oncogenic role in tumorigenesis is through unleashed cell proliferation,G1 / S transition,inhibition of apoptosis and Chromatin instability. It is an independent biomarker that can affect tumour＇s process,prognosis and survival rate. The underlying mechanisms of CHD1 L activation may disrupt the cell death program via binding the apoptotic protein Nur77 or exterting relevant function by mediate CHD1L＇s target genes（ ARHGEF9,TCTP,SPOCK1,and NTKL）. This paper mainly introduces its oncogenic role and research progress of related molecular mechanism.
出处
《医学研究生学报》
CAS
北大核心
2016年第4期445-448,共4页
Journal of Medical Postgraduates
基金
江西省自然科学基金(20151BAB205010)
