摘要
目的探讨白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)和白细胞介素-17(IL-17)在儿童紫癜性肾炎(HSPN)发病机制中的相关性。方法收集2013年3月至2015年4月我院住院治疗的83例HSPN患儿作为研究对象,采用双抗体夹心ELISA法检测HSPN患儿IL-1β、IL-6、IL-17血清水平,同期选取健康儿童29例作为正常对照组。结果 HSPN组患儿血清中IL-1β、IL-6、IL-17较正常对照组均明显升高差异有统计学意义(P<0.05),HSPN组血清中IL-6女性明显高于男性差异具有统计学意义,P<0.05。结论 IL-1β、IL-6和IL-17均参与了儿童HSPN的发病过程,在其炎症期起促进炎症作用。
Objective To investigate the pathogenesis of interleukin-1beta（IL-1beta）,interleukin-6（IL-6）and interleukin-17（IL-17）in children with Henoch Schonlein purpura nephritis（HSPN）.Method From March,2013 to April,2015,83 cases of HSPN children be treated in our hospital as the research object,The expression of concent ration of IL-1beta.IL-6.IL-17 in blood serum was tested with ELISA.Over the same period,twenty healthy children were selected as healthy control group.Result The level of IL-1beta,IL-6and IL-17 were significantly higher in children with HSPN compared with the healghy control group（P〈0.05）,the serum of IL-6were higher in females than in males in HSPN（P〈0.05）,and there were statistical significantly differences.Conclusion IL-1beta,IL-6and IL-17 may involve in the course of HSPN and play a role in the inflammatory stage.
出处
《贵州医药》
CAS
2015年第12期1068-1070,共3页
Guizhou Medical Journal
基金
原贵州省卫生厅科技基金资助
