摘要
目的:探讨血清神经生长因子(NGF)与CK-MB水平变化对病毒性心肌炎患儿的临床意义。方法:选择40例心肌炎患儿,分别于急性期和恢复期空腹抽取静脉血3mL,采用ELISA法检测血清NGF,速率法检测CK-MB。选取同期健康体检儿童40例,采用同样的方法检测血清NGF和CK-MB。结果:心肌炎患儿NGF和CK-MB在急性期较恢复期及对照组的水平显著增高,均存在统计学意义(P<0.01);通过Pearson相关性分析,病毒性心肌炎患儿急性期血清NGF与CK-MB呈正相关(r=0.866,P<0.05)。结论:血清NGF高表达可能参与心肌炎的发病机制,演绎放大炎症作用。
Objective：To investigate the significance of serum nerve growth factor （NGF）in children with viral myocarditis.Methods：The serum levels of NGF was detected by two-site enzyme-linked immunosorbent assay （ELISA）and CK-MB by rate method at the acute and convalescent in 40 infants with myocarditis,and 40 normal healthy children as the control. Results：The serum levels of NGF in acute myocarditis were significantly higher than those in healthy children and the convalescent（P 〈 0.01 ）.By Pearson correlation analysis,the serum NGF levels and CK-MB content in the children with viral myocarditis showed positive correlation（r= 0.866,P 〈 0.05 ）.Conclusion：Serum NGF expression may be involved in the pathogenesis of myocarditis.
出处
《内蒙古医科大学学报》
2015年第6期534-537,共4页
Journal of Inner Mongolia Medical University
基金
内蒙古自治区自然科学基金项目(2009MS1101)
