摘要
目的探讨血管紧张素原(AGT)基因多态性与儿童过敏性紫癜(HSP)及紫癜性肾炎(HSPN)的相关性。方法使用病例对照研究,经PCR和RFLP方法检测AGT基因型。结果AGT基因型构成比在患病组与对照组、HSPN组与对照组之间差异有统计学意义(χ2=17.92、17.08,P均<0.01),但在HSP和HSPN之间差异无统计学意义(χ2=1.78,P=0.41)。AGT-TT基因型在患病组和HSPN组均明显高于对照组(P<0.01)。结论用标记物对过敏性紫癜以及紫癜性肾炎易感性的追踪提示,AGT M235T基因型与中国儿童HSP、HSPN之间有关联。
Objective To explore the relationship between angiotensinogen （AGT） gene polymorphism with Henoch-Schonlein purpura syndrome （HSP） and Henoch-Schonlein purpura nephritis （HSPN） in children. Methods The AGT genotype were obtained by polymerase chain reaction-restriction fragment length polymerase （PCR-RFLP） with a case control approach. Results The AGT genotype distribution was significantiy different between all patients and normal control, and between HSPN and normal control （X^2= 17.92, 17.08, P 〈 0.01）, but no difference was observed between HSP and HSPN （X^2 = 1.78, P = 0.41 ）. There was a higher frequency of AGT gene TT genotype and T allele among all patients and HSPN patients when compared to normal control （P 〈 0.01 ）. Conclusions Tracking the suscepti- bility of HSP and HSPN by markers suggest that the AGT M235T polymerase is significantly associated with HSP and HSPN in children in China.
出处
《临床儿科杂志》
CAS
CSCD
北大核心
2009年第4期314-316,共3页
Journal of Clinical Pediatrics
关键词
血管紧张素原
基因多态性
过敏性紫癜
紫癜性肾炎
儿童
angiotensinogen
gene polymorphism
Henoch-Schonlein purpura
Henoch-Schonlein purpura nephritis
children
