摘要
目的:探讨纳米甘薯渣纤维素对糖尿病大鼠血糖及血脂的影响。方法:选用40只雄性Sprague-Dawley(SD)大鼠随机分组为5组,其中1组大鼠喂食基础饲料作为空白组,另外4组采用链脲佐菌素(streptozotocin,STZ)诱导大鼠建立糖尿病模型,分为模型对照组(MC组)、普通甘薯渣纤维素组(OC组)、微晶甘薯渣纤维素组(MCC组)和纳米甘薯渣纤维素组(CNC组),实验期28 d,测定大鼠体质量、采食量、空腹血糖、糖化血清蛋白、血清胰岛素、肝糖原及血脂水平等指标。结果:模型对照组大鼠的采食量,空腹血糖、糖化血清蛋白、血脂水平均显著高于空白组(P<0.05),体质量、胰岛素和肝糖原含量明显下降(P<0.05),说明造模成功,糖尿病大鼠表现出相应的症状。喂食不同粒度甘薯渣纤维素的糖尿病大鼠,其体质量、血清胰岛素和肝糖原水平有所增加,而空腹血糖、糖化血清蛋白、血脂水平等都有所下降,其中喂食纳米甘薯纤维素的糖尿病大鼠指标变化具有显著性差异(P<0.05)。结论:从甘薯渣纤维素粒度分析,可以看出随着甘薯渣纤维素粒度的减小,其对糖尿病大鼠血糖血脂的调节作用愈加明显,其中纳米甘薯渣纤维素具有较好的调节血糖血脂水平的作用。
Objective： To investigate the effects of cellulose nanocrystals from sweet potato residues on the levels of blood glucose and serum lipid in diabetic rats. Methods： Forty mature male SD rats were divided into five groups. One group was fed with a basal diet as control group（CON）. The other four groups were subjected to intraperitoneal injection of streptozotocin（STZ） to establish diabetic rat models. The rats were fed with the basal diet and dietary fiber, assigned into model control（MC）, ordinary cellulose（OC）, microcrystalline cellulose（MCC） and cellulose nanocrystals（CNC） groups. All rats were sacrificed after 28 days of feeding to assay body weight, food intake, fasting plasma glucose, glycosylated serum protein, serum insulin, liver glycogen, and serum lipids. Results： Compared with the control group, food intake, fasting plasma glucose, glycosylated serum protein, and serum lipids in the model control were significantly higher（P〈0.05）; however body weight, insulin and hepatic glycogen significantly declined（P〈0.05）. The results suggested the diabetic model was successfully established and the diabetic rats showed corresponding symptoms. Feeding sweet potato fibers with different granularities to diabetic rats could result in an increase in body weight and the levels of serum insulin and glycogen and a decrease in fasting glucose, glycosylated serum protein and blood lipids. In contrast, feeding cellulose nanocrystals caused significant changes in all these parameters（P〈0.05）. Conclusion： The hypoglycemic and hypolipidemic effects of sweet potato residue fiber were more obvious with decreasing granularity. Therefore, cellulose nanocrystals from sweet potato residues can effectively regulate the levels of blood glucose and serum lipid.
出处
《食品科学》
EI
CAS
CSCD
北大核心
2015年第21期227-232,共6页
Food Science
基金
中央高校基本科研业务费专项资金项目(XDJK2014D017)
关键词
纳米甘薯渣纤维素
糖尿病大鼠
糖化血清蛋白
胰岛素
血脂
cellulose nanocrystals from sweet potato residues
diabetic rats
glycosylated serum protein
insulin
serum lipid
