摘要
目的研究食管鳞状细胞癌(ESCC)中HIF-1α、EGFR蛋白的表达与食管癌病理特征及预后的关系。方法采用免疫组织化学(SP)法检测116例ESCC组织中HIF-1α、EGFR蛋白的表达,并分析其与临床病理因素及患者生存的关系。结果 HIF-1α与EGFR在ESCC组织中的阳性率分别为63.8%和68.1%,HIF-1α与EGFR均阳性率为50.9%。HIF-1α蛋白的阳性表达与T分期相关(P=0.014)。联合检测HIF-1α和EGFR蛋白均阳性表达与浸润深度及临床分期相关(P=0.006,0.023)。HIF-1α与EGFR蛋白表达呈正相关(r=0.331,P=0.000)。Kaplan-Meier生存分析结果显示,EGFR蛋白阳性表达的ESCC患者生存时间短(P=0.019)。结论 HIF-1α、EGFR蛋白在ESCC组织中呈高表达,二者密切相关,在ESCC发生发展中有重要作用,EGFR可作为判断预后的重要指标。
Objective To investigate the relationship between the expression of epithelial growth factor receptor（EGFR）,hy-poxia -inducible factor -1 α（HIF -1 α）and clinical characteristics and prognosis in esophageal squamous cell carcinoma（ES-CC）.Methods 1 1 6 cases of ESCC were analyzed about their clinical pathology and survival data.The expression of HIF -1 α, EGFR were detected by immnohistochemical staining.Results The positive rates of high expression of HIF -1 αand EGFR were 63.8% and 68.1 %.Positive rate of co -expression of HIF -1 αand EGFR was 50.9%.The expression of HIF -1 αwas correlated with T stage（P =0.01 4）,and the co -expression was correlated with T and TNM stage （P =0.006,0.023）. Spearman rank correlation analysis illustrated that there was a significant correlation between HIF -1 αand EGFR.Kaplan -Meier survival analysis showed that high -expression of EGFR were associated with poor survival.Conclusion HIF -1 αand EGFR played an important role in the development and progression of ESCC,and show intimate relationship with biological be-havior.EGFR may be used as an important index to evaluate the prognosis of esophageal carcinoma.
出处
《河南医学研究》
CAS
2015年第5期1-4,共4页
Henan Medical Research
基金
河南省医学科技攻关计划项目(201003125)
关键词
食管肿瘤
鳞状细胞癌
乏氧诱导因子
-1
α
表皮生长因子受体
预后
esophageal neoplasm
squamous cell carcinoma
hypoxia -inducible factor -1 α
epithelial growth factor receptor
prognosis
