摘要
目的探讨不同放疗敏感性宫颈癌组织中HIF-lα蛋白的表达及其与放疗敏感性的关系。方法选取宫颈鳞癌(Ⅱb、Ⅲa期)患者40例,放疗前行宫颈组织活检并保存标本。放疗结束3个月后,根据WHO实体瘤疗效判断标准,将保存的宫颈癌组织标本分为高敏感组(28例)及低敏感组(12例),应用免疫组织化学方法检测组织中HIF-lα蛋白的表达。结果 HIF-lα蛋白在高敏感组的表达强度高于低敏感组,差异有统计学意义(P<0.05);HIF-lα蛋白在Ⅲa期患者宫颈癌组织中的表达强度稍高于Ⅱb组,差异有统计学意义(P<0.05)。结论乏氧诱导因子-lα可能是导致宫颈癌放疗敏感性下降的一个重要因素。
Objective To study the expression of HIF-lα in human cervical squamous cell carcinoma tissues and its association with radiosensitivity. Methods 40 samples from patients with cervical squamous cell carcinoma（Ⅱb, Ⅲa）were collected and preserved before radiotherapy.Then the samples were divided into two groups： the high radio-sensitivity group and the low radio-sensitivity group, according to according to the WHO response evaluation criteria in solid tumors in 3 months after the end of radiotherapy. The HIF-lα protein were detected by immunohistochemistry technology in tissue. Results The expression levels of HIF-lα in the low radio-sensitivity group were higher than those in the high radio-sensitivity group significantly（P〈0.05）; The expression levels of HIF-lα in the stage Ⅲa were higher than those in the stage Ⅱb significantly（P〈0.05）. Conclusion HIF-lα may be an important factor resulting in decreased sensitivity of cervical carcinoma in radiotherapy.
出处
《中国医药指南》
2014年第18期60-62,共3页
Guide of China Medicine
关键词
乏氧诱导因子-lα
宫颈癌
放射敏感性
Hypoxia-inducible factor-1α
Cervical carcinoma
Radiosensitivity
