摘要
目的:探讨间质细胞衍生因子-1α(stromal cell-derived factor-1α,SDF-1α)的表达与胃癌淋巴结转移的关系.方法:应用免疫组织化学检测SDF-1α在152例胃癌组织中的表达,将表达结果与患者临床病理特征进行相关性分析,并对胃癌淋巴结的转移危险因素进行单因素分析和多因素分析.结果:SDF-1α表达与肿瘤淋巴管浸润(P=0.016)和淋巴结转移(P=0.003)密切相关,而与患者年龄、性别、肿瘤部位、肿瘤大小、大体分型、浸润深度和组织分化程度(P>0.05)等无相关性;未分化的组织学(HR=3.312;95%CI:1.414-7.825,P=0.008)、淋巴管浸润(HR=11.215;95%CI:2.780-45.978,P=0.002)和S D F-1α(H R=3.194;95%C I:1.313-7.296,P=0.013)是胃癌患者的危险因素;未分化的组织学(HR=3.054;95%CI:1.176-8.614,P=0.039)、淋巴管浸润(H R=8.651;95%CI:1.731-44.959,P=0.008)和SDF-1α(HR=2.219;95%CI:1.327-10.346,P=0.015)是胃癌患者淋巴结转移的独立危险因素.结论:SDF-1α可能是胃癌患者淋巴结转移的独立危险因素.
AIM： To explore the relationship between the expression of stromal cell-derived factor-la （SDF-1a） and lymph node metastasis in gastric cancer patients.METHODS： The expression of SDF-1a in gastric cancer tissues from 152 patients was detected by immunohistochemistry. The correlations of SDF-1a with clinicopathologic features were analyzed. RESULTS： SDF-1a expression was significantly correlated with tumor lymphatic vessel invasion （P = 0.016） and lymph node metastasis （P = 0.003）, but not with patients age, gender, tumor size, gross type, depth of invasion or degree of differentiation （P = 0.003）. Undifferentiated histology （HR = 3.312; 95%CI： 1.414-7.825, P = 0.008）, lymphatic vessel invasion （HR=11.215; 95%CI： 2.780-45.978, P = 0.002） and SDF-1a expression （HR = 3.194; 95%CI： 1.313-7.296, P = 0.013） were identified to be risk factors for gastric cancer. Undifferentiated histology （HR = 3.054; 95%CI： 1.176-8.614, P = 0.039）, lymphatic vessel invasion （HR = 8.651; 95%CI： 1.731-44.959, P = 0.008） and SDF-1a expression （HR = 2.219; 95%CI： 1.327-10.346, P = 0.015） were also identified to be independent risk factors for lymph node metastasis in gastric cancer patients. CONCLUSION： SDF-1a may be an independent risk factor for lymph node metastasis in gastric cancer.
出处
《世界华人消化杂志》
CAS
2015年第12期1897-1902,共6页
World Chinese Journal of Digestology
关键词
间质细胞衍生因子1α
胃癌
淋巴结转移
Stromal cell-derived factor-1a
Gastriccancer
Lymph node metastasis
