摘要
目的 观察肝动脉化疗栓塞术联合功能性脾动脉血流栓塞术治疗原发性肝细胞癌合并脾功能亢进的临床效果及不良反应.方法 将80例原发性肝细胞癌合并脾功能亢进患者应用计算机随机分为两组,观察组行肝动脉化疗栓塞术联合功能性脾动脉血流栓塞术,对照组仅行肝动脉化疗栓塞术,观察治疗后碘油沉积情况、血常规变化情况及术后不良反应.结果 （1）术后1个月行腹部CT扫描,观察组38例（79.2％）碘油沉积超过50％,对照组27例（84.4％）.（2）观察组脾栓塞术后1周白细胞计数为（7.6±2.3）×10^9/L,术后1个月为（5.8±1.9）×10^9/L,术后3个月为（5.0±1.7）×10^9/L,均较术前[（2.2±1.1）×10^9/L]升高,差异均有统计学意义（P均＜0.05）;术后1周血小板计数为（93±29）×10^9/L,术后1个月为（127±32）×10^9/L,术后3个月为（119±26）×10^9/L,均较术前[（39±20）×10^9/L]升高,差异均有统计学意义（P均＜0.05）;对照组术后与术前比较差异均无统计学意义（P均＞0.05）.（3）两组患者术后均未出现严重不良反应.结论 肝动脉化疗栓塞术联合功能性脾动脉血流栓塞术治疗原发性肝细胞癌合并脾功能亢进安全、有效.
Objective To observe the therapeutic effects and comphcations of treatment by using transcatheter arterial chemombolization（TACE） combined with functional splenic embolization（FSE） on patients with primary hepatocelluar carcinoma （HCC） combinded with hypersplenism.Methods Eighty HCC patients with hypersplenism were randomly divided into two groups by computer program.Observation group was treated with TACE and FSE,while control group was treated by only TACE.The iodine oil deposition,blood routine parameters and related complications were observed.Results （1） After one-month＆#39; s treatment,abdominal CT scan showed that 38 cases（79.17%） of patients in the observation group and 27 cases （84.38%） of patients in control group had iodine oil deposition in over 50% of the tumor area.（2） The white blood cell counting in observation group were （7.65 ± 2.3） × 10^9/L,（5.89 ± 1.9） × 10^9/L,（5.02 ± 1.7） × 10^9/L in the follow-up examination 1 week,1month and 3 month after splenic embolization,respectively,which were significantly increased from the preoperative level of （2.21 ± 1.1） × 10^9/L（P 〈 0.05）.Platelets counting were （93 ± 29）× 10^9/L,（127 ± 32） × 10^9/L and （119 ± 26） × 10^9/L in observation group at 1 week,1 month and 3 month after splenic embolization,respectively,which were significantly higher than the preoperative level of （39 ± 20）× 10^9/L （P 〈 0.05）.In the control group,there were no statistically significant difference between the preoperative and postoperative levels （P 〉 0.05）.（3） Both of the the two groups showed no serious complications.Conclusion TACE combined with FSE is a safe and an effective method to treat hypersplenism combined in HCC patients.
出处
《中国综合临床》
2014年第12期1309-1311,共3页
Clinical Medicine of China
