摘要
以系列L-氨基酸衍生物作为手性修饰剂,研究了三苯基膦(tpp)稳定的1.0%Ru/γ-Al2O3催化剂催化芳香酮多相不对称加氢,考察了稳定剂种类、修饰剂种类、金属负载量、底物浓度、温度、压力等因素对不对称加氢反应的影响。结果表明,L-氨基酸衍生物对1.0%Ru/γ-Al2O3/2tpp催化剂具有较好的修饰作用,在优化反应条件下芳香酮加氢反应的对映选择性达33%-81%,苯乙酮加氢反应的对映选择性可达70%。
The asymmetric hydrogenation of aromatic ketones catalyzed by L-amino acid derivative-and PPh3-modified 1. 0%Ru/γ-Al2O3 was studied. The effects of different stabilizers,modifiers,ruthenium content,substrate concentration,temperature and pres-sure on the asymmetric hydrogenation of aromatic ketones were investigated in detail. The results showed that L-amino acid deriva-tive had good modification effects on the 1. 0%Ru/γ-Al2 O3/2tpp catalyst. Under the optimum conditions,the hydrogenation enanti-oselectivities ofaromatic ketoneswere 33%-81%. The enantioselectivity of the hydrogenation product of acetophenone could reach 70%.
出处
《化学研究与应用》
CAS
CSCD
北大核心
2014年第12期1875-1880,共6页
Chemical Research and Application
基金
国家自然科学基金项目(21201184)资助
重庆市科委自然科学基金计划项目(cstc2014jcyj A10105)资助
重庆市教委自然科学基金项目(KJ1400601)
重庆市百名学术学科领军人才培养计划项目资助
关键词
钌
L-氨基酸衍生物
芳香酮
不对称加氢
ruthenium
L-amino acid derivative
aromatic ketones
asymmetric hydrogenation
