摘要
以金鸡纳碱衍生物作为手性修饰剂,研究了三苯基膦稳定的1.0%Ru+0.2%Rh/γ-Al2O3催化剂催化芳香酮多相不对称加氢,考察了修饰剂种类及浓度、碱添加剂种类及浓度、溶剂、氢气压力等因素对不对称加氢反应的影响.结果表明,金鸡纳碱衍生物对1.0%Ru+0.2%Rh/γ-Al2O3-tpp催化剂具有较好的修饰作用,在优化反应条件下苯乙酮加氢反应的对映选择性高达84%.
The asymmetric hydrogenation of aromatic ketones catalyzed by cinchona- and PPh3-modified 1.0% Ru＋0.2% Rh/y-Al2O3 was studied. The effects of different modifiers, modifier concentration, different base additives, base additive concentration, solvents, and hydrogen pressure on the asymmetric hydro- genation of aromatic ketones were investigated in detail. The results showed that cinchona alkaloids had good modification effects on the 1.0% Ru＋0.2% Rh/γ-Al2O3-tpp catalyst. Under the optimum conditions, the hydrogenation enantioselectivity of acetophenone was up to 84%.
出处
《化学学报》
SCIE
CAS
CSCD
北大核心
2012年第3期297-302,共6页
Acta Chimica Sinica
基金
重庆市科委自然科学基金计划(No.CSTC
2011BA5025)
重庆市教委自然科学基金(No.KJ100701)
重庆工商大学科研启动基金(No.2010-56-14)
重庆市科技创新团队(No.KJTD201020)资助项目~~
关键词
钌
铑
金鸡纳碱
芳香酮
不对称加氢
ruthenium
rhodium
cinchona alkaloids
aromatic ketones
asymmetric hydrogenation
