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金鸡纳碱衍生物修饰的Ru/γ-Al_2O_3催化芳香酮不对称加氢研究 被引量：2

Study on asymmetric hydrogenation of aromatic ketones catalyzed by cinchona-modified Ru /γ-Al_2O_3
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摘要 本文以金鸡纳碱衍生物作为手性修饰剂,研究了三苯基膦(tpp)稳定的1.0%Ru/γ-Al2O3催化剂催化芳香酮多相不对称加氢,考察了修饰剂种类、修饰剂浓度、金属负载量、底物浓度、温度、压力等因素对不对称加氢反应的影响。结果表明,金鸡纳碱衍生物对1.0%Ru/γ-Al2O3/2tpp催化剂具有较好的修饰作用,在优化反应条件下萘乙酮加氢反应的对映选择性达85%,苯乙酮加氢反应的对映选择性可达83%。 The asymmetric hydrogenation of aromatic ketones catalyzed by cinchona-and PPh3-medified 1.0% Ru/T-AI203 was stud- ied. The effects of modifiers, modifier concentration, ruthenium content, substrate concentration, temperature and pressure on the asymmetric hydrogenation of aromatic ketones were investigated in detail. The results showed that cinchona a/kaloids had good modification effects on the 1.0% Ru/γ-Al2O3/2tpp catalyst. Under the optimum conditions, the hydrogenation enantioselectivity of acetonaphthone was 85%. The enantioselectivity of the hydrogenation product of aeetophenone could reach 83%.
作者 蒋和雁 陈华
机构地区 重庆工商大学药物化学与化学生物学研究中心 四川大学化学学院有机金属络合催化研究所
出处 《化学研究与应用》 CAS CSCD 北大核心 2013年第11期1484-1490,共7页 Chemical Research and Application
基金 国家自然科学基金项目(21201184)资助 重庆市科委自然科学基金计划项目(CSTC 2011BA5025)资助 重庆市百名学术学科领军人才培养计划项目资助
关键词 钌 金鸡纳碱 芳香酮 不对称加氢 ruthenium cinchona alkaloids aromatie ketones asymmetrie hydrogenation
分类号 O625.42 [理学—有机化学]
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参考文献33

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二级参考文献86

共引文献27

同被引文献23

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化学研究与应用
2013年 第11期

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