(1S,2S)-DPEN修饰的负载型钌-铑双金属催化剂催化苯乙酮及其衍生物的不对称加氢被引量：9

Asymmetric Hydrogenations of Acetophenone and Its Derivatives over RuRh/γ-Al_2O_3 Modified by (1S,2S)-DPEN and PPh_3

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摘要制备了以三苯基膦(PPh_3)作为助剂的Ru-Rh/γ-Al_2O_3催化剂,在氢氧化钾的异丙醇溶液中,用(1S,2S)-DPEN[(1S,2S)-1,2-diphenylethane-1,2-diamine]作手性修饰剂对苯乙酮及其衍生物进行不对称催化加氢,此催化剂表现出较高的催化活性和良好的对映选择性.优化反应条件,苯乙酮、乙基苯基酮和异丙基苯基酮的转化率分别达到92.5%,95.9%,100%,生成(R)-构型产物的ee值分别达到79.6%、81.2%和81.4%. The asymmetric hydrogenations of acetophenone and its derivatives over the bimetallic catalyst RuRh/γ- Al2O3 modified by PPh3 and （1S, 2S）-DPEN [（1S, 2S）-1,2-diphenylethane-1,2-diamine] were studied. The effects of the concentration of KOH, temperature, ratio of ruthenium to rhodium, and the concentration of diamine on the asymmetric hydrogenation of acetophenone were investigated in detail. The results showed that this catalyst system had high activity and moderate enantioselectivity for the asymmetric hydrogenation of acetophenone and its derivatives. Under the optimum conditions, the conversions of acetophenone, ethylphenylketone, and isopropylphenyl-ketone were up to 92.5%, 95.9%, and 100%, and the enantioselectivities for the formation of （R）-aromatic alcohols were 79.6%, 81.2%, and 81.4%, respectively.

作者刘德蓉熊伟杨朝芬王金波陈华李瑞祥李贤均

机构地区四川大学化学学院有机金属络合催化研究所绿色化学及技术教育部重点实验室重庆科技学院化学与生物工程学院

出处《物理化学学报》 SCIE CAS CSCD 北大核心 2007年第4期479-483,共5页 Acta Physico-Chimica Sinica

关键词钌铑双金属催化剂苯乙酮不对称加氢 Ruthenium Rhodium Bimetallic catalyst Acetophenone Asymmetric hydrogenation

分类号 O643.32 [理学—物理化学]

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参考文献27

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